Iyeon Papaverine Hydrochloride Injection

Adult dosage

Oral: 200mg of papaverine hydrochloride should be taken divided into 3-4 doses per day. Injection: 30-50mg of papaverine hydrochloride should be subcutaneously administered once per injection, totaling 100-200mg per day. For acute arterial embolism, 50mg should be injected intra-arterially once, for acute pulmonary embolism, 50mg should be injected intravenously once. Dosage should be adjusted based on age and symptoms.

This drug is an ampule injection and care should be taken when cutting the glass container to avoid glass fragments mixing in. Special caution should be taken while administering to children or elderly patients. It should not be used in patients with hypersensitivity to this drug or those with a history of such hypersensitivity, as well as in patients with cardiac conduction abnormalities. Patients with glaucoma should be cautious as this drug can increase intraocular pressure and exacerbate symptoms. During administration, respiratory depression may occur, so the patient's breathing status should be closely monitored and administration should be stopped immediately if any abnormalities are detected. Signs of hepatic function anomalies may rarely appear, so careful monitoring of liver condition is required. Caution is necessary as neurological symptoms such as dizziness, drowsiness, headaches can occur, as well as gastrointestinal symptoms such as constipation, dry mouth, appetite loss. If skin rashes or facial flushing occur, administration should be stopped immediately. Symptoms such as elevated blood pressure or increased heart rate may appear, necessitating careful monitoring of the cardiac condition. This drug may cause prolonged erections, so it is not recommended for treating erectile dysfunction. There may be interactions with other medications, especially when used with levodopa, so caution is advised. Women who are pregnant or breastfeeding should be administered carefully as the safety of this drug has not been fully established. The safety and efficacy in children have not been sufficiently clarified, so caution is advised regarding its use. Elderly patients may have reduced physical function, thus special caution regarding dosage adjustment is necessary. When administering intravenously, care should be taken not to inject too quickly, and care should be taken to prevent glass fragments from entering when opening the ampule. This drug may produce precipitate when mixed with certain injection solutions, so do not mix, and it should be administered separately from X-ray contrast agents. Cases of death due to serious side effects related to intravenous use have been reported, so particular care is required during administration.

Serious side effects

Respiratory depression, hepatic hypersensitivity (including jaundice), severe edema or urination abnormalities accompanied by elevated blood pressure

Mild side effects

• Dizziness
• drowsiness
• headaches
• excessive sedation
• lethargy
• constipation
• dry mouth
• substernal pain
• appetite loss
• nausea

This drug should be stored in a sealed container that blocks light. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Ampule containing a colorless, transparent liquid

Package unit

1mL/ampule × 50