Anidipine Tablet (Amlodipine Maleate)

Adult dose

Administer 5 mg orally once daily as amlodipine, and if symptoms do not improve within 2 to 4 weeks, the dose may be increased to a maximum of 10 mg daily according to the patient's response. Adjust dosage appropriately based on symptoms.

This medication should not be used in certain patients. For example, individuals allergic to this medication or its ingredients, pregnant women or those who may become pregnant, nursing mothers, patients with cardiogenic shock, severe aortic stenosis, unstable angina, recent myocardial infarction, severe liver dysfunction, or hypotension should not take this drug. Furthermore, it should be administered with caution to patients with severely impaired kidney function, elderly patients, those with acute heart failure, severe hypertension crises, mild to moderate liver dysfunction, left ventricular functional impairment, low cardiac reserve, or diabetes. This medication is generally well tolerated, but during use, symptoms such as facial flushing, warmth, fatigue, edema, palpitations, dizziness, headaches, nausea, drowsiness, and ankle swelling may occur. Rarely, hypotension, syncope, sensory disturbances, erectile dysfunction, skin rashes, liver function disturbances, or allergic reactions may occur; any unusual symptoms should be reported to healthcare professionals immediately. Discontinuation of this medication suddenly may worsen symptoms, so dosage should be reduced slowly according to a doctor's guidance. Adequate water should be taken while on this medication, and caution is advised when driving or operating dangerous machinery due to potential dizziness or drowsiness. This medication may interact with specific drugs, so if taking other medications, it is essential to inform healthcare professionals, especially as taking it with grapefruit juice may increase blood pressure-lowering effects, thus should be avoided. During pregnancy or lactation, as safety has not been established, use should be avoided, and its use in children is not recommended due to the lack of confirmed safety and efficacy. Elderly patients may experience elevated serum concentrations of this medication, so it should be started at a low dosage and administered cautiously. In case of overdose, severe hypotension and cardiac issues may arise, requiring immediate emergency care. This medication should be kept out of reach of children, and it is advisable not to transfer it to other containers. Long-term use has shown no reported risks of carcinogenicity or mutagenicity.

Serious side effects

Urticaria, angioedema, toxic epidermal necrolysis, possibility of severe allergic reactions, hepatitis, jaundice, elevated liver enzyme levels, potential for liver abnormalities (jaundice), Stevens-Johnson syndrome, severe skin adverse reactions, severe swelling, thrombocytopenia, leukopenia, respiratory depression accompanied by rhinitis, difficulty breathing, cardiogenic shock, severe hypotension, severe swelling, severe neurological symptoms (confusion, paralysis)

Mild side effects

• Flushing with warmth
• fatigue
• edema
• palpitations
• dizziness
• headache
• migraine
• weakness
• abdominal pain
• nausea

This medication should be stored in a tightly closed container to prevent air or moisture from entering and should be kept at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness over time.

Appearance

White or light yellow dodecagonal tablets

Package unit

30 tablets/bottle, 300 tablets/bottle