Feringanit 0.1% Injection (Nitroglycerin)

Adult administration

The appropriate dose of this medicine varies among individuals; adjust it according to the patient's condition while monitoring hemodynamic parameters. The usual recommended dose is 10-200㎍/min as nitroglycerin, and it may be increased to 400㎍/min if necessary. 1. Perioperative blood pressure control: For the treatment of intraoperative hypertension or induction of hypotension, administer an initial dose of 25㎍/min, then repeat 25㎍/min at 5-minute intervals until blood pressure stabilizes. For myocardial ischemia, administer an initial dose of 15-20㎍/min, then repeat 10-15㎍/min until an effect is observed. 2. Congestive heart failure: Administer an initial dose of 20-25㎍/min, then repeat 10㎍/min or 20-25㎍/min at 15-30-minute intervals according to the patient's condition. 3. Angina pectoris: Administer an initial dose of 10㎍/min, then repeat 10㎍/min at 30-minute intervals according to the patient's condition. Administer this medicine diluted with normal saline injection or dextrose injection, or inject it slowly into a vein using a syringe without dilution. When diluting, calculate the amount of this medicine required based on the actual volume to be infused. For example, to obtain a diluted solution of this medicine at a concentration of 100㎍/ml, mix 50ml of this medicine injection (50mg nitroglycerin) with 450ml of diluent to make a total volume of 500ml. Adjust the dose appropriately according to age and symptoms. The exact dilution method or dose and the corresponding drip rate are shown in the following table. Administration concentration (μg/min): 100, 200, 300, 400 Volume of this medicine (ml): 50, 100, 150, 200 Volume of diluent (ml): 450, 400, 350, 300 Volume of diluted injection (ml): 500, 500, 500, 500 Microdrops/min (ml/hour) / Drops/min / Dose (μg/min) 10: 6, 2 20: 12, 4 30: 18, 6 40: 24, 8 50: 30, 10 60: 36, 12 70: 42, 14 80: 48, 16 90: 54, 18 100: 60, 20 110: 66, 22 120: 72, 24 130: 78, 26 140: 84, 28 150: 90, 30 Dose (μg/min) for each row: 100, 200, 300, 400 *1ml = 60 pediatric microdrops = 20 standard drops **When used without dilution (using a syringe pump) Concentration of injection: 1,000 μg/ml Infusion rate (ml/hour): 0.6, 0.9, 1.2, 1.5, 1.8, 2.4, 3.0, 4.5, 6.0, 9.0, 12.0, 15.0, 18.0, 21.0, 24.0 Dose (μg/min): 10, 15, 20, 25, 30, 40, 50, 75, 100, 150, 200, 250, 300, 350, 400

This medication is provided in an injectable form, and care must be taken to avoid glass fragments when breaking the container. Extra caution is required when used in children or the elderly. This medication should not be administered to specific patients, such as those allergic to this drug or other nitrate preparations, those with severe hypotension, reduced blood volume, anemia, acute circulatory failure, severely impaired heart function, patients with elevated intracranial pressure, and glaucoma patients. In addition, administering this medication to patients taking PDE-5 inhibitors or sGC stimulators can cause severe hypotension. Patients with poor liver or kidney function, hypotensive individuals, pregnant or breastfeeding women, children, and the elderly should use this medication with increased caution and consult a physician if necessary. This medication may cause side effects such as increased heart rate, headache, dizziness, hypotension, skin rash, nausea, etc. Headaches are common due to its vasodilatory effects, and if the symptoms are severe, analgesics should be taken or a doctor consulted. During administration, blood pressure and cardiac status should be closely monitored, and any unusual symptoms should be reported to medical personnel immediately. Care should also be taken as this drug may adsorb to specific plastic materials, so appropriate infusion containers and sets must be used, paying attention to infusion rates. This medication may enhance the hypotensive effects when taken with other antihypertensive agents or alcohol; therefore, caution is recommended during co-administration. Pregnant or breastfeeding women should strictly follow the physician's instructions as administration may affect the fetus or infant. In cases of overdose, symptoms such as severe hypotension, methemoglobinemia, headache, and dizziness may occur, requiring immediate treatment. This medication may affect reaction times when driving or operating machinery, so caution is advised during use, especially in combination with alcohol. Finally, this medication should be used immediately after opening, and any remaining drug should not be stored but discarded. If it comes into contact with skin, symptoms such as palpitations or headaches may occur, necessitating immediate rinsing with clean water.

Tachycardia, worsening of angina symptoms, arrhythmia, palpitations, orthostatic hypotension, a state of exhaustion accompanied by arrhythmia and fainting, hypotension, flushing, prolonged hypotension after discontinuation, rebound phenomenon, headache, dizziness, drowsiness, heavy feeling in the head, cerebral edema, nausea, vomiting, heartburn, abdominal pain, dry mouth, allergic skin reactions, allergic contact dermatitis, exfoliative dermatitis, skin erythema, weakness, itching, burning sensation, erythema, irritation, chest discomfort, muscle cramps, oliguria, fatigue, metabolic acidosis, increased heart rate, anxiety, pallor, sweating, methemoglobinemia, headache, increased heart rate, nausea, weakness, exhaustion, fainting, diarrhea, rapid breathing, anxiety, cyanosis, increased intracranial pressure

This medication should be stored in a sealed container to prevent air from entering, with a storage temperature maintaining room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the drug's effectiveness and safety.

Appearance

Colorless, transparent injection solution filled in a colorless, transparent ampoule

Package unit

10 ampoules/box [(10 milliliters/ampoule × 10)]