Tegretol CR 200 mg (Carbamazepine)

Adult dose

1. Epilepsy Start treatment at a low dose and increase it slowly until the optimal effect is achieved. Adjust the dose of this medicine to adequately control seizures in each individual patient. Determining the blood concentration may help achieve the optimal dose. The therapeutic blood concentration of carbamazepine for epilepsy is known to be 4-12 μg/mL (17-50 micromoles/L). Adults: Administer an initial dose of carbamazepine 200-400㎎ per day orally in 1-2 divided doses, and increase it slowly until the optimal effect is achieved (600㎎ per day). The dose may be increased to 1200㎎ per day according to symptoms. 2. Trigeminal neuralgia Adults: The initial dose of this medicine is 200-400㎎ per day, given in divided doses up to 600 mg per day. The dose may be increased to 800mg per day according to symptoms. 3. Mania, manic states in manic-depressive illness, and states of excitement in schizophrenia Adults: Administer an initial dose of this medicine of 200-400㎎ per day in 1-2 divided doses, and increase it slowly until the optimal effect is achieved (600㎎ per day). The dose may be increased to 1200㎎ per day according to symptoms. Adjust the dose according to age and symptoms.

Child dose

Children: Administer 100-600㎎ per day in divided doses according to age and symptoms.

This medication may increase the risk of suicidal thoughts or behaviors; therefore, changes in mood or symptoms of depression should be closely monitored during treatment. Serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur while taking this medication, so if skin rash, blisters, or mucosal inflammation develop, consult a physician immediately. Taking this medication during pregnancy may pose risks of fetal anomalies or growth disorders, hence women who are pregnant or planning to become pregnant should consult a physician and use effective contraception. This medication should not be given or should be used cautiously in patients with certain blood disorders, heart disease, liver disease, or kidney disease, and regular blood tests and liver function tests are needed before and during treatment. During the initial dose or dose adjustment, central nervous system side effects such as dizziness, drowsiness, and movement coordination disturbances can frequently occur, so it is advisable to avoid driving or operating dangerous machinery when these symptoms occur. This medication has many drug interactions and requires caution when used in combination, particularly it may decrease the effectiveness of contraceptives, so non-hormonal contraceptive methods are recommended. In the event of an overdose, serious symptoms such as central nervous system depression, respiratory depression, and heart arrhythmias may occur, necessitating immediate medical attention for appropriate treatment. This medication should be kept out of reach of children and stored in its original container for safety. It is important to consult medical personnel immediately if any adverse reactions or suspicious symptoms occur during treatment.

Suicidal ideation, suicidal behavior, depression, abnormal changes in mood and behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, leukopenia, thrombocytopenia, eosinophilia, leukocytosis, lymphadenopathy, agranulocytosis, aplastic anemia, pancytopenia, pure red cell aplasia, anemia, megaloblastic anemia, reticulocytosis, hemolytic anemia, fever, rash, vasculitis, lymphoproliferative disorder, arthralgia, hepatic splenomegaly, abnormal liver function test results, biliary atresia syndrome, angioedema, hypogammaglobulinemia, anaphylactic reaction, edema, fluid retention, weight gain, hyponatremia, somnolence, vomiting, headache, confusional state, neurological disorders, galactorrhea, gynecomastia, folic acid deficiency, decreased appetite, acute intermittent porphyria, mixed porphyria, delayed cutaneous porphyria, hyperammonemia, visual hallucinations, auditory hallucinations, depression, aggressive behavior, anxiety, restlessness, confusional state, activation of psychosis, ataxia, dizziness, drowsiness, diplopia, headache, dysregulation, tremor, fixed posture abnormality, dystonia, facial spasms, nystagmus, oral-facial movement disorders, oculomotor disorders, speech disorders, chorea, peripheral neuropathy, sensory disturbances, incomplete paralysis, taste disturbances, neuroleptic malignant syndrome, myotonic muscular spasms, aseptic meningitis, dysregulation, lens opacity, conjunctivitis, increased intraocular pressure, hearing impairment, auditory hyperacusis, hearing loss, auditory perception disorders, electrocardiogram abnormalities, bradycardia, arrhythmias, syncope, exacerbation of coronary artery disease, congestive heart failure, retinopathy, lymphadenopathy, myocardial infarction, hypertension, hypotension, circulatory collapse, embolism, thrombotic venous inflammation, PIE syndrome, fever, respiratory distress, pneumonia, vomiting, nausea, thirst, constipation, diarrhea, abdominal pain, pancreatitis, glossitis, stomatitis, cholestatic hepatitis, jaundice, biliary atresia syndrome, severe hepatitis, granulomatous hepatitis, hepatic failure, urticaria, allergic dermatitis, exfoliative dermatitis, erythroderma, systemic lupus erythematosus symptoms, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, photodermatosis, erythema multiforme, nodular erythema, skin pigmentation abnormalities, purpura, acne, hyperhidrosis, alopecia, hirsutism, muscle weakness, osteomalacia, osteoporosis, arthralgia, myalgia, muscle cramps, tubulointerstitial nephritis, renal failure, renal impairment, urinary retention, frequency of urination, sexual dysfunction, erectile dysfunction, sperm production abnormalities, fatigue, increased γ-GTP, elevated alkaline phosphatase, elevated transaminases, increased intraocular pressure, elevated cholesterol, increased high-density lipoprotein, increased triglycerides, abnormal thyroid function tests, increased prolactin, reactivation of herpesvirus 6 infection, bone marrow failure, sedation, memory impairment, colitis, drug rash accompanied by eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, lichen planus, nail loss, fracture, oral edema, vesicular rash, pustular rash, mucosal rash, sleep disturbances, hypersomnia

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is important to keep it in a cool place below 30 degrees Celsius.

Appearance

Pale yellow-orange rectangular extended-release film-coated tablet

Package unit

100 tablets/box [(10 tablets/PTP packaging X 10)], 50 tablets/box [(10 tablets/PTP packaging X 5)]