Glucozen Tablet 500 mg (Metformin Hydrochloride)

Adult dose

Dosage should be determined based on individual drug response and tolerance, without exceeding the recommended maximum daily dose. Start with a low dose and take 500 mg 2 to 3 times daily with meals. Increase the dosage gradually by 500 mg weekly, typically administering 2000 mg in two divided doses in the morning and evening. If exceeding 2000 mg, take in three divided doses with meals, with a maximum of 2550 mg per day.

Child dose

Children over 10 years of age and adolescents in growth should take 500 mg once daily during or after meals. Measure blood sugar levels after one week to adjust dosage. The maximum daily dosage is 2000 mg.

This medication can cause severe lactic acidosis or hypoglycemia; if these symptoms occur, immediately inform medical personnel and discontinue use. It should not be used in patients with moderate or severe renal impairment, dehydration, serious infections, cardiovascular collapse, acute myocardial infarction, sepsis, or other acute conditions. Patients with acute or unstable heart failure, or those undergoing examinations using radiological iodine contrast agents should not be administered this medication. Patients who have had allergic reactions to this medication or other biguanide medications, those with type 1 diabetes, or history of lactic acidosis or ketoacidosis are also excluded from use. Patients with severe infections or severe traumatic systemic disorders should temporarily discontinue this medication until oral intake is restored and renal function returns to normal. If undergoing surgery, this medication should be stopped 48 hours before the procedure and can be resumed after confirming normal renal function post-surgery. This medication is not recommended for patients with liver dysfunction, pneumothorax, severe pulmonary dysfunction, excessive alcohol intake, dehydration, or gastrointestinal disorders. This medication contains lactose, so patients with lactose intolerance or related genetic disorders should not take it. Patients who have irregular meals or insufficient food intake, engage in vigorous exercise, or are taking interacting medications are at risk for lactic acidosis and hypoglycemia and should use the medication cautiously. During treatment with this medication, adverse effects such as gastrointestinal disturbances, metallic taste, skin rashes, anemia, vitamin B12 deficiency, liver dysfunction, or hypoglycemia may occur; if any unusual symptoms arise, consult healthcare personnel. Regularly monitor renal function to prevent the accumulation of this medication and the risk of lactic acidosis, especially in the elderly or those with renal function decline who need to be tested more frequently. Continuously monitor blood sugar control, and if blood sugar is poorly controlled or new symptoms arise during treatment, inform healthcare personnel immediately. Alcohol can interfere with the lactate metabolism of this medication, increasing risks, so it is important to avoid excessive drinking while on this medication. This medication may interact with other hypoglycemic agents or various medications, so when administered together, closely monitor blood sugar and condition according to healthcare personnel's instructions. During pregnancy, this medication crosses the placenta; women who are planning to become pregnant or are pregnant should consult healthcare personnel before use and should not use it if there is a risk of placental insufficiency or preeclampsia. Women who are breastfeeding should carefully decide whether to continue breastfeeding or discontinue medication, as this medication is excreted in breast milk. For children and the elderly, dosages should be adjusted carefully, and renal function should be monitored regularly. In case of overdose, hypoglycemia is rare; however, the medication can accumulate in the body, and treatment such as hemodialysis may be necessary. This medication does not cause weight gain and helps achieve stable blood sugar control and a reduced risk of diabetes complications with long-term use. Keep out of reach of children and do not transfer to other containers for safety.

Serious side effects

• Lactic acidosis
• severe allergic reactions (such as rash)
• severe edema
• hypoglycemia

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, anorexia, dyspepsia, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, hypoglycemia

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle