Prenazone (Methylprednisolone)

Adult dosage

The initial dose may vary from 4 mg to 48 mg of methylprednisolone per day, depending on the symptoms of the specific disease. For treatment of acute exacerbations of multiple sclerosis, administration of 200 mg of prednisolone daily for 1 week followed by 80 mg of prednisolone every other day for 1 month is effective (4 mg of methylprednisolone is equivalent to 5 mg of prednisolone). Alternate-day therapy means administering twice the daily dose in the morning on one day out of every 2 days. The initial suppressive dose should be continued until a satisfactory clinical response is achieved, which is usually 4 to 10 days for many allergic and collagen diseases. Gradually reduce the amount of corticosteroid administered on alternate days. As disease progression is controlled, reduce the daily corticosteroid dose to the minimum effective dose as soon as possible, then switch to an alternate-day schedule. Administering 3 times or even 4 times the daily dose on alternate days is preferable to doubling the daily dose. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours

This medication should not be used in patients with certain allergic reactions or severe infections. In particular, administration in cases of viral infections such as herpes simplex, shingles, or chickenpox can worsen symptoms. Patients who have received live vaccines or have genetic issues such as lactose intolerance should also avoid this medication. Patients with certain conditions such as glaucoma, tuberculosis, hypertension, thrombosis, and peptic ulcers should use this medication cautiously as symptoms may worsen. This medication can cause various side effects, including fluid retention, muscle weakness, gastrointestinal problems, skin changes, and psychological symptoms, so symptoms should be closely monitored. If used for a long time, abrupt discontinuation can cause serious issues like adrenal insufficiency, so it should be gradually reduced. During the use of this medication, patients may become more susceptible to infections, so care should be taken to avoid exposure to infections like chickenpox or measles. Additionally, it can interact with various medications, so consult with a professional if taking other medications. During pregnancy or breastfeeding, it should only be used when necessary as it may affect the fetus or baby. In children and the elderly, there is a higher risk of growth delay or side effects, so it should be administered more cautiously. Regular check-ups and strict adherence to the doctor's instructions are necessary for safe treatment.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femur and humerus, steroid myopathy, muscle wasting, pathologic fractures of the pelvis, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, gastric pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, suppression of skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, nipple edema, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, symptoms of latent diabetes mellitus, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased requirements for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior subcapsular cataract, secondary infections of the eye, retinal disorders, exophthalmos, negative nitrogen balance due to protein catabolism, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to store it at room temperature, between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

White round tablet

Package unit

30 tablets/bottle, 500 tablets/bottle