Choiil Pharmaceutical Sodium Cytidine Injection 250 mg (mL)

Adult administration

1. Disturbances of consciousness due to head trauma or brain surgery Adults: Administer 100 ∼ 500 mg of citicoline per dose intramuscularly or by intravenous infusion 1 ∼ 2 times daily. 2. Hemiplegia following stroke Administer 1,000 mg of this medicine intravenously once daily for 4 consecutive weeks. Alternatively, administer 250 mg intravenously once daily for 4 weeks. If improvement is observed, continue injections for an additional 4 weeks. 3. Pancreatitis In combination with a protease inhibitor, administer 1,000 mg of this medicine intravenously once daily for 2 weeks.

Since this medication is an ampoule injection, glass fragments may be mixed in when cutting the container, so caution is required during use. Special attention is needed when used for children or the elderly. Patients who have allergic reactions to this medication or its components should not be administered this medication. Caution should be exercised when administering it to patients with a history of drug allergies or consciousness disturbances after acute severe head trauma or brain surgery, and in such cases, hemostatic agents or measures against increased intracranial pressure and hypothermia may be necessary. For patients with consciousness disturbances in the acute phase of cerebral infarction, it is preferable to start administration within 2 weeks after the stroke occurs. Rarely, shock symptoms may occur when using this medication, so if signs such as hypotension, chest tightness, or difficulty breathing appear, administration should be stopped immediately, and appropriate treatment should be provided. Administration should also be halted in the event of allergic reactions such as skin rashes. Occasionally, neurological symptoms such as insomnia, headaches, dizziness, agitation, and seizures may appear, and in patients with post-stroke hemiparesis, the sensation in the paralyzed area may become more intense. Gastrointestinal symptoms such as nausea or loss of appetite may occur, and liver function test values may become abnormal. Transient diplopia, heat sensation, blood pressure fluctuations, and fatigue may also occur rarely. In patients with acute severe head trauma or consciousness disturbance after brain surgery, this medication should be used in conjunction with hemostatic agents, antihypertensive agents, and hypothermia treatment. This medication may increase the efficacy of the drug levodopa when administered together, so caution is needed. Pregnant women or women of childbearing potential should only use this medication when the benefits of treatment outweigh the risks, as its safety has not been established. Its safety in pediatric patients has not been sufficiently confirmed, so cautious use is required. Elderly patients may have impaired body functions, so dosage should be carefully adjusted such as reducing the amount administered. When administered by intramuscular injection, care should be taken to avoid nerves or blood vessels, administering only the minimum required amount, and if there is severe pain or blood backflow at the injection site, the site should be changed immediately. When administered intravenously, it is advisable to inject as slowly as possible.

• shock
• hypotension
• chest tightness
• shortness of breath
• rash
• insomnia
• headache
• dizziness
• agitation
• convulsion

This medication should be stored in a sealed container to prevent air or moisture from entering and kept in a cool room away from direct sunlight. Proper storage can help maintain the effectiveness of the medication for a longer duration.

Appearance

Colorless transparent ampoule injection containing a colorless transparent liquid

Package unit

10 ampoules/box [2 milliliters/ampoule*10], 10 ampoules/box [4 milliliters/ampoule*10]