B. Braun 5% Dextrose and Physiological Saline Injection

Adult administration

For an average adult, administer 500 to 1,000 mL per day in 2 to 3 divided doses by slow intravenous infusion. The infusion rate is 250 to 500 mL per hour (60 to 120 drops per minute), and for the elderly, the rate is 250 mL per hour (60 drops per minute).

Child administration

For infants and young children, administer 15 to 60 mL per hour (4 to 15 drops per minute).

This medication is an injection containing dextrose, which may significantly increase the consumption of thiamine (Vitamin B1) in the body during intravenous infusion, posing a risk of fatal thiamine deficiency. It should not be administered to patients in states of fluid overload, osmotic dehydration, hypokalemia, or hypernatremia. Caution should be exercised in patients with impaired renal function, heart failure, osmotic dehydration, obstructive uropathy, diabetes, hyperchloremia, and severe hyponatremia. Rapid or large-volume administration of this medication may result in adverse effects such as cerebral edema, pulmonary edema, peripheral edema, acidosis, and water intoxication, with the risk of water intoxication particularly high in neonates and premature infants when infused quickly. Care is needed as a thrombus may form at the injection site. During administration, blood glucose, serum electrolytes, and fluid balance must be regularly checked to ensure there are no abnormalities. The container of this medication is made of PVC that contains DEHP, a plasticizer known to affect reproductive development in animal tests; however, the risk is very low in actual use, and there is no need to avoid using this medication. Use during pregnancy should only occur when the therapeutic benefits outweigh the potential risks to the fetus, and during labor, care should be taken regarding changes in blood glucose levels for both the mother and newborn. Particularly in neonates, infants, and the elderly, rapid or prolonged administration should be avoided, and blood glucose levels and condition should be closely monitored. In cases of overdose, the use of diuretics may be required to eliminate excess fluid. Prior to administration, skin and equipment should be disinfected to prevent infection, and the product should be warmed to body temperature from a cold state before use. Any remaining solution must be discarded after opening. Infusion should be done slowly intravenously, and care must be taken to avoid introducing air into the container to prevent air embolism. This medication should be stored at room temperature, with special care taken during storage.

Serious side effects

Severe edema (cerebral edema, pulmonary edema, peripheral edema), seizures, coma, brain damage.

Mild side effects

• Cerebral edema
• pulmonary edema
• peripheral edema
• acidosis
• water intoxication
• thrombosis
• hyperglycemia
• hypoglycemia
• seizures
• coma

This medication must be stored in a sealed container to prevent air or moisture from entering. It should be kept away from excessively hot or cold environments and ideally stored at normal room temperature.

Appearance

A colorless to pale yellow aqueous injection solution filled in a polyethylene container.

Package unit

Bottle - 500 milliliters/bottle, Bottle - 1000 milliliters/bottle