Seractil 300 mg (Dexibuprofen D.C.)

Adult dose

○ Adults: Administer 300 mg per dose orally 2～4 times daily as dexibuprofen. However, do not exceed 1,200 mg of dexibuprofen per day.

This drug may cause gastric bleeding in individuals who regularly consume more than 3 alcoholic beverages daily; therefore, one must consult a doctor or pharmacist. Non-steroidal anti-inflammatory drugs including this medication may increase the risk of serious cardiovascular events such as cardiovascular thrombotic reactions, myocardial infarction, and stroke. Patients with cardiovascular diseases or risk factors should be particularly cautious and closely monitor cardiovascular symptoms during use. This drug may increase the risk of serious gastrointestinal adverse reactions including gastrointestinal bleeding, ulcers, and perforation, especially in the elderly or with long-term use. Symptoms of gastrointestinal bleeding or discomfort should prompt immediate consultation with healthcare professionals. This drug should not be used in patients with a history of gastrointestinal ulcers, bleeding, severe blood disorders, liver dysfunction, renal dysfunction, heart failure, hypertension, or asthma. Caution is advised when taken in conjunction with aspirin or other non-steroidal anti-inflammatory drugs, as this may increase the risk of gastrointestinal adverse reactions. During use, breastfeeding should be discontinued or the medication should be stopped, and caution should be exercised when driving or operating machinery due to possible dizziness or fatigue. Individuals with blood disorders, liver or kidney disease, hypertension, heart failure, or a history of hypersensitivity should consult a healthcare professional before use. If severe adverse reactions occur including shock, severe skin rash, blood disorders, liver function abnormalities, gastrointestinal symptoms, or difficulty breathing, the medication should be stopped immediately, and medical advice sought. Regular blood tests and liver and kidney function tests are necessary with long-term or high-dose use, and it should be remembered that this drug is symptomatic relief. Pregnant women beyond 6 months should not take this medication due to potential effects on the fetus, and after 20 weeks of pregnancy, it should only be used at the minimum dose for the shortest period while regularly checking amniotic fluid status. In case of overdose, medical treatment should be sought immediately even if there are no symptoms, and gastric lavage or dilution may be necessary. This medication should be stored in a cool, dry place out of reach of children, avoiding direct sunlight, and the lid must be kept tightly closed.

• Gastrointestinal bleeding
• cardiovascular thrombotic reaction
• myocardial infarction
• stroke
• bleeding from the stomach or intestines
• ulcers
• perforations
• dyspepsia
• abdominal bloating
• heartburn

Drug interactions

Do not take this medication in conjunction with aspirin, other non-steroidal anti-inflammatory drugs, or high doses of methotrexate. Also avoid corticosteroids, alcohol, digoxin, phenytoin, probenecid, sulfinpyrazone, sulfonylureas, ACE inhibitors or angiotensin II receptor antagonists, diuretics, lithium, coumarin anticoagulants (such as warfarin), baclofen, and immunosuppressants (cyclosporine, tacrolimus, sirolimus).

This medication may be sensitive to air and humidity, thus it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1°C and 30°C to preserve the effectiveness and safety of the drug.

Appearance

White oval film-coated tablet.

Package unit

30 tablets/bottle, 300 tablets/bottle