Diprofen Tablet 300 mg (Dexibuprofen D.C.)

Adult dose

○ Adults: Administer 300 mg of dexibuprofen per dose orally 2～4 times daily. Do not exceed 1,200 mg of dexibuprofen per day.

This drug may cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic beverages per day; therefore, consultation with a doctor or pharmacist is essential. This drug can affect the cardiovascular system and increase the risk of severe cardiovascular diseases such as myocardial infarction or stroke. Particularly, caution should be exercised in those with pre-existing cardiovascular conditions or risk factors, and immediate medical consultation is advised if symptoms occur. This drug can cause serious gastrointestinal adverse reactions, including gastrointestinal bleeding, ulcers, and perforations, and should be used with extreme caution in individuals with a history of gastrointestinal diseases or the elderly. Gastrointestinal symptoms should be closely monitored during treatment, and immediate medical attention is required if abnormalities arise. Some patients may experience severe health issues such as blood abnormalities, liver dysfunction, kidney impairment, heart failure, or hypertension while using this drug, thus individuals with these conditions should consult a specialist before use. The risk of cardiovascular and gastrointestinal adverse reactions may increase if this drug is taken with other non-steroidal anti-inflammatory drugs or aspirin, so co-administration is not recommended. Caution is needed while driving or operating machinery as dizziness or drowsiness may occur during the treatment. Pregnant individuals in their sixth month or beyond should avoid taking this drug. This drug can be passed through breast milk, so it should be avoided during breastfeeding or mothers should refrain from breastfeeding. If severe allergic reactions, skin rashes, difficulty breathing, severe gastrointestinal symptoms, liver dysfunction, or kidney impairment occur, the medication should be stopped immediately and consult a healthcare professional. This drug should be used at the minimum effective dose for the shortest duration necessary, and regular blood tests and liver and kidney function tests are required for long-term use. During pregnancy, especially after the 20th week, the duration and dosage must be strictly limited due to potential impacts on fetal kidney function, and amniotic fluid status should be monitored via ultrasound if necessary. In the event of an overdose, seek immediate medical attention even if no symptoms are present. Store out of reach of children, protect from direct sunlight, and store in a cool, dry place.

Rarely, shock (chest discomfort, chills, difficulty breathing, low blood pressure, etc.), rarely aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, agranulosis, pancytopenia, thrombocytopenia, impaired platelet function (prolonged bleeding time), eosinophilia, and other blood disorders; dyspepsia, abdominal distension, heartburn, upper abdominal pain, diarrhea or constipation, occasionally anorexia, nausea, vomiting, abdominal pain, discomfort in the stomach, or rarely esophagitis, esophageal stricture, exacerbation of diverticulitis, nonspecific hemorrhagic colitis, ulcerative colitis or Crohn's disease, peptic ulcer gastrointestinal bleeding, perforation, blood in stool, gastritis, pancreatitis; very rarely, dry mouth, stomatitis, erythema multiforme, systemic lupus erythematosus (SLE), hair loss, occasionally angioedema, rarely mucocutaneous syndrome (Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell syndrome), drug rash with eosinophilia and systemic symptoms (DRESS syndrome), occasionally rash, urticaria, itching, purpura; rarely triggers asthma attacks, eczema, anaphylaxis, photosensitivity reactions; very rarely jaundice, elevated ALT, elevated AST, elevated ALP, liver dysfunction, hepatitis, jaundice; occasionally rhinitis, bronchospasm, acute pneumonia; rarely neglect, visual disturbances such as scotoma, hearing loss, tinnitus, taste disturbance, fatigue, drowsiness, headache, dizziness, occasionally anxiety, restlessness, confusion, depression; rarely aseptic meningitis, severe headache, nausea, vomiting, insomnia, stiffness of the neck, fever or altered consciousness; rarely psychiatric disturbances, agitation, excitement, disorientation, reversible toxic amblyopia; rarely decreased blood pressure, increased blood pressure, palpitations, oliguria, hematuria, proteinuria, elevated BUN, elevated serum creatinine, hyperkalemia, decreased urine output, generalized edema with concomitant shortness of breath, lethargy; rarely renal papillary necrosis, nephrotic syndrome, interstitial nephritis, peripheral edema, acute pulmonary edema, fluid retention, hypertension, heart failure, decreased reproductive capacity in women, occasionally periorbital edema; very rarely, fatigue, fever, nosebleeds, exacerbation of inflammation, in case of these occurrences, stop taking the medication immediately and consult a doctor or pharmacist.

Drug interactions

Do not take this drug with aspirin, other non-steroidal anti-inflammatory drugs, or high doses of methotrexate. Before taking this drug, consult regarding corticosteroids, alcohol, digoxin, phenytoin, probenecid, sulfinpyrazone, sulfonylureas, ACE inhibitors or angiotensin II receptor antagonists, diuretics, lithium, coumarin anticoagulants, baclofen, immunosuppressants, thrombolytics, ticlopidine, antiplatelet drugs.

This drug may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1 to 30 degrees Celsius to maintain the drug's efficacy and safety over time.

Appearance

Orange oblong film-coated tablet

Package unit

1000 tablets/bottle, 30 tablets/bottle