Innoen Dobutamine Premix 100 mg Injection

Adult administration

In adults, administer dobutamine by intravenous injection at a rate of 2.5-10 μg/kg/min. For satisfactory effects, an infusion rate of 40 μg/kg/min may rarely be required. The dosing and treatment duration should be determined based on measurements of heart rate, exercise tolerance, blood pressure, urine output, central venous pressure, or wedge pressure, and cardiac output. Cases have been reported where doses of up to 5,000 μg/ml were administered, and the final dose should be based on the patient's needs.

This medication should not be used in patients with certain heart conditions. For example, it should not be administered to patients with unexplained aortic stenosis or those allergic to this medication, or patients with inflammation or pressure around the heart. Additionally, patients allergic to corn or corn products should not use dextrose solution containing this medication. It should be used with caution in patients with increased heart rate or blood pressure, as patients with hypertension may experience exacerbated blood pressure. Patients with severe occlusion of coronary vessels may experience imbalance in cardiac blood flow when using this medication, which may put strain on the heart. In patients with atrial fibrillation, the electrical signals in the heart may be stimulated more, potentially increasing ventricular rate, so caution is advised. Caution is also required for patients with heart rhythm abnormalities or severe hypotension. This medication contains sodium bisulfite, which may cause allergic reactions or severe respiratory distress in some patients, especially those with asthma. Dextrose-containing IV solutions should not be administered with blood as they can increase the risk of blood cell aggregation or destruction. During intravenous infusion, there is a risk of electrolyte dilution or symptoms of pulmonary edema due to excess hydration, so caution is necessary. Excessive administration of solutions without potassium can lead to low potassium levels in the blood, causing health issues. During administration of this medication, continuous monitoring of blood pressure, heart rate, ECG, and urine output should be done, and appropriate treatment should be administered to patients whose cardiac function deteriorates rapidly. Patients with hypovolemia may require volume resuscitation before administration of this medication. Combining this medication with beta-blockers may reduce its effectiveness, so caution is advised. In cases of severe aortic stenosis or severe blood flow obstruction, the effects of this medication may not manifest. The safety of this medication has not been established in acute myocardial infarction patients, and caution is advised as it may place additional strain on the heart. If heart rate or blood pressure rises excessively during administration, appropriate measures such as dose reduction may be necessary. Long-term administration may develop tolerance, necessitating an increase in dosage. Patients with diabetes or those at risk for diabetes should exercise caution when using dextrose-containing IV solutions. This medication may affect cardiac function when used with certain vasodilators, and side effects may occur when used with specific drugs, so consulting healthcare professionals is essential. Women who are pregnant or may become pregnant should carefully consider the risks and benefits of using this medication, and it is advisable to avoid administration during breastfeeding or to discontinue breastfeeding. Safety and efficacy in pediatric populations have not been sufficiently established. Elderly patients may have decreased physiological functions, so administration should begin at a lower dosage and be monitored closely. This medication should only be administered by slow intravenous infusion, and care should be taken to avoid inflammation or necrosis at the injection site. Do not mix this medication with certain solutions or store it for extended periods, and keep it away from excessive heat or ice during storage. In case of overdose, blood pressure or heart rate may change excessively, so dosing should be reduced or administration temporarily halted until stability is achieved.

Serious side effects

Shortness of breath (breathing problems).

Mild side effects

• Rash
• fever
• eosinophilia
• bronchospasm
• tachycardia
• extrasystoles
• excessive hypertension
• angina
• precordial warmth
• chest discomfort

This medication should be stored in a sealed container to prevent exposure to air or moisture, and it is best to keep it in a cool place below 25 degrees Celsius. This way, the medication's effectiveness can be maintained for a longer period.

Appearance

A colorless or pale yellow transparent injectable solution filled in a clear plastic container for intravenous administration.

Package unit

500 milliliters