Loxodiphen Tablets (Loxoprofen Sodium Hydrate)

Adult dose

1. For efficacy and indication 1 and 2: ○ Adults: Take 60 mg of loxoprofen sodium (anhydrous) orally three times a day. For single-dose therapy, take 60 to 120 mg orally. 2. For efficacy and indication 3: ○ Adults: Take 60 mg of loxoprofen sodium (anhydrous) orally. Principally, it can be administered twice a day, with a maximum daily dosage of 180 mg. It is advisable to take the drug on an empty stomach.

This medication poses a risk of gastrointestinal bleeding in individuals who regularly consume more than three alcoholic drinks daily; it is essential to consult a doctor or pharmacist before use. Patients with cardiovascular diseases or risk factors should be cautious, as this medication may worsen cardiovascular problems such as myocardial infarction or stroke. This medication may cause serious gastrointestinal side effects like bleeding, ulcers, and perforation, especially in the elderly or those with a history of gastrointestinal disease, and should be taken with caution. Patients with peptic ulcers, severe liver impairment, kidney impairment, heart failure, or allergies to this drug or its components should not take this medication. Patients with a history of asthma or aspirin allergy may experience severe allergic reactions when taking this medication; it is crucial to inform healthcare providers before administration. Periodic blood tests and assessments of liver and kidney function are required for long-term use; if any adverse symptoms appear, medication should be immediately discontinued, and a doctor should be consulted. If allergic symptoms such as rash, itching, hives, difficulty breathing, or low blood pressure occur, stop taking the medication immediately and seek emergency assistance. If there are symptoms like indigestion, abdominal pain, nausea, vomiting, or blood in stools, discontinue the medication and inform healthcare personnel immediately. Using this medication in combination with other non-steroidal anti-inflammatory drugs may increase the risk of side effects, so it is best to avoid concurrent use. During late pregnancy, this medication should not be used as it can severely impact the fetus; during early to mid-pregnancy, it should be used cautiously at the minimum effective dose under the guidance of a doctor. It is safest for breastfeeding women to avoid taking this medication. Elderly patients have a higher risk of side effects, such as gastrointestinal bleeding or reduced kidney function, when taking this medication, so special precautions are necessary. This medication is not recommended for children as its safety has not been established in pediatrics. There may be interactions with other medications; therefore, patients should inform their doctor or pharmacist of any currently taken medications. Store this medication out of children's reach and do not transfer it to other containers.

Serious side effects

Hives, severe swelling (angioedema, facial swelling, periorbital swelling, oral swelling), tightness in chest, difficulty breathing, anaphylactic-like symptoms, shock, low blood pressure, gastrointestinal bleeding (hematemesis, melena, hematochezia), severe gastrointestinal ulcers, perforation, colonic perforation, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, mucocutaneous syndrome, erythema multiforme, acute generalized exanthematous pustulosis, DRESS syndrome), asthma attack

Mild side effects

• Hives
• rash
• itching
• fever
• drowsiness
• numbness
• dizziness
• headache
• abdominal pain
• gastric discomfort

This medication may be sensitive to air or moisture and should be stored in a tightly closed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature. Storing it this way helps maintain the medication's effectiveness safely.

Appearance

White round tablet

Package unit

30 tablets/bottle, 500 tablets/bottle