Pentolmin Injection (Pentolamine Mesylate)

Adult administration

1. For controlling hypertension in patients with pheochromocytoma before or during surgery, administer 2 to 5 mg intravenously. Monitor blood pressure changes and repeat as necessary. 2. Diagnostic block test for suspected pheochromocytoma: - Intravenously: Rapidly administer 5 mg and measure blood pressure at 30 to 60-second intervals afterward. - Intramuscularly: Administer 5 mg and record blood pressure every 5 minutes for 30 to 45 minutes.

This medication can significantly lower blood pressure, which may increase the risk of heart attack or cerebrovascular issues, so caution is necessary. It should not be used in patients with low blood pressure or those with heart-related conditions. Patients who are allergic to this medication or sensitive to sulfites should avoid it. Patients with gastritis, peptic ulcers, or poor kidney function should use it cautiously. Blood pressure changes should be frequently monitored during administration, and if it drops too low, immediate treatment should be sought. Dizziness may occur while using this medication, so it is advisable to avoid driving or operating dangerous machinery. Caution should be exercised when using it simultaneously with other antihypertensive medications or antipsychotics, as this may enhance the hypotensive effect. Pregnant or breastfeeding women should use it cautiously after consulting with a physician and may consider stopping breastfeeding if necessary. Elderly patients may have reduced physiological functions, so it is preferable to use a reduced dosage. In cases of overdose, blood pressure may drop too low, and abnormalities in heart rhythm may occur, necessitating immediate medical attention. When using the injection, care should be taken to avoid the introduction of glass fragments, and if there is pain or abnormal symptoms at the injection site, the needle should be removed immediately and a different site used for injection.

Serious side effects

• Hypotension leading to shock
• myocardial infarction
• cerebral infarction
• cerebrovascular spasm
• cerebrovascular occlusion
• angina
• acute asthma attack
• shock
• confusion

Mild side effects

• Sedation
• loss of appetite
• dizziness
• weakness
• headache
• warmth
• back pain
• sweating
• lethargy
• abdominal discomfort

This medication should be stored in a tightly closed container to prevent air or moisture from entering, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain its effectiveness over time.

Appearance

An ampoule containing a clear colorless to light yellow liquid

Package unit

1 mL/ampoule × 10