Pidi Tablet (Methylprednisolone)

Adult dosage

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. For treatment of acute exacerbations of multiple sclerosis, it is effective to administer prednisolone 200mg daily for 1 week, followed by prednisolone 80mg every other day for 1 month (4mg of methylprednisolone is equivalent to 5mg of prednisolone). Alternate-day therapy means administering twice the daily dose on one morning every 2 days. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in four divided doses every 6 hours, the initial suppressive-dose period is usually 4 to 10 days for many allergic and collagen diseases. Gradually reduce the amount of corticosteroid administered every other day. It is preferable to administer 3 or even 4 times the daily dose every other day rather than twice the daily dose.

This medication should not be administered to certain patients under any circumstances. For example, it is not used in patients who are allergic to this drug or its components, or in those with infections where appropriate antibiotics are unavailable, as well as in patients with herpes simplex, herpes zoster, and varicella. Furthermore, patients who have received live vaccines or have genetic issues like lactose intolerance should also avoid this medication. This medication should be used cautiously in some patients. Special attention is required when administering this drug to patients with glaucoma, tuberculosis, cataracts, hypertension, thrombosis, peptic ulcers, psychiatric disorders, osteoporosis, diabetes, renal insufficiency, hypothyroidism, hepatic fat deposition, myasthenia gravis, elderly patients, and those with epilepsy. Patients with infections or past medical histories of various conditions need careful monitoring. Care should be taken when using this medication as various side effects may appear. Potential side effects include fluid retention, edema, increased blood pressure, muscle weakness, osteoporosis, gastrointestinal issues, skin changes, neuropsychiatric disturbances, endocrine abnormalities, and ocular problems. Particularly, long-term use can lead to serious side effects such as adrenal insufficiency, hence the medication should not be discontinued abruptly but tapered gradually as directed by a healthcare provider. As this medication suppresses immune function, the risk of infections may increase. Patients should avoid exposure to infectious diseases such as varicella or measles, and if infection is suspected, they should consult healthcare professionals immediately. Additionally, live vaccinations should be avoided while on this medication. This medication can interact with various other drugs; therefore, if other medications are being taken, it is essential to inform healthcare providers. Some drugs may reduce the effectiveness of this medication or increase the risk of side effects, necessitating dose adjustments or monitoring. Women who are pregnant or may become pregnant should only take this medication when the benefits outweigh the risks as it may have effects on the fetus. Moreover, lactating women are advised to discontinue breastfeeding since this medication may be transmitted through breast milk. Pediatric and adolescent patients may experience side effects such as growth retardation, hence the lowest effective dose should be used, with careful monitoring of growth status. Elderly patients have a higher risk of adverse effects including infections, diabetes, osteoporosis, hypertension, cataracts, and glaucoma, and should be treated cautiously with close monitoring of their condition. Finally, this medication may reduce the efficacy of certain vaccines and can affect skin test results, thus caution is needed during testing. Rarely, severe allergic reactions or other serious side effects may occur; if any unusual symptoms develop, medical consultation should be sought immediately.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral epiphyses, steroid myopathy, loss of muscle mass, pathological fractures of the pelvis, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, gastric pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial flushing, thin and fragile skin, abnormal sweating, petechiae, purpura, suppression of skin reactions, purpura, acne, hirsutism, hair loss, hyperpigmentation, breast swelling, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, symptoms of latent diabetes mellitus, secondary adrenal insufficiency, pituitary unresponsiveness, impaired glucose tolerance, increased requirements for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior subcapsular cataract, secondary infection, retinal disorders, exophthalmos, negative nitrogen balance, immune system disorder, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. This helps preserve the effectiveness and safety of the medication for a longer duration.

Appearance

White round tablets

Package unit

30 tablets/bottle, 200 tablets/bottle, 300 tablets/bottle