Dae Han Magnesium Sulfate Injection 50%

Adult administration

○ Cramps due to hypomagnesemia: Administer 1 to 2 g of magnesium sulfate intravenously (4.05 to 8.1 mmol). ○ Eclampsia seizures: Administer 4 to 5 g of this medication intravenously over 10 minutes (16.2 to 20.25 mmol). ○ Prevention of uterine contractions: Administer an initial dose of 4 g intravenously (16.2 mmol). A further 1 g dose may be given. ○ Electrolyte replenishment (hypomagnesemia): Administer 1 g intramuscularly 4 times every 6 hours, or 5 g can be added to a 5% dextrose injection or 0.9% saline for intravenous administration over 3 hours. When treating for deficiency, the patient's renal excretory function must be closely monitored. ○ Pediatrics: The safety for pediatric use has not been tested.

Child administration

The safety for pediatric use has not been tested.

This medication is in the form of a glass ampule injection, so care must be taken when opening the ampule to avoid the risk of glass shards mixing in. Great care should be taken when administering it to children or the elderly. This medication should not be administered to patients with impaired kidney function, those with altered consciousness, patients with high magnesium levels in the blood, patients with cardiac conduction abnormalities, and patients with myasthenia gravis. Caution should be exercised when using this medication in children with intestinal parasitic infections or patients with heart disease. When using this medication, gastrointestinal symptoms such as vomiting or dry mouth may occur, and rarely symptoms like irregular heartbeats, vasodilation, headaches, tremors, and tingling may occur. Additionally, in cases of overdose, magnesium toxicity can lead to severe symptoms such as warmth, thirst, low blood pressure, central nervous system depression, decreased heart rate, and respiratory arrest, so caution is advised. In such cases, calcium preparations can be administered intravenously for detoxification. This medication may enhance central nervous system depression effects when used with barbiturates, narcotics, and other general anesthetics. Additionally, using it with iron supplements, specific antibiotics, sodium fluoride, etc., may reduce the absorption of these medications, so caution is necessary. It can also affect absorption with isoniazid, chlorpromazine, and digoxin, and when used with muscle relaxants, the muscle relaxant effect may increase. It can be used to treat eclampsia during pregnancy, but it may pass through the placenta and affect the fetus, causing decreased muscle tone, decreased reflexes, and low blood pressure. Administration during delivery may pose a risk of decreased newborn respiration, so the fetal heart rate should be closely monitored, and it should not be used within 2 hours after delivery. During prolonged or repeated use, the calcium and magnesium levels of the fetus and any skeletal anomalies should be monitored. Safety during lactation has not been established, and it is best not to administer it unless in special cases. Elderly patients may have reduced physical function, so the administration rate should be slowed down, and the dosage should be reduced, using caution. In cases of overdose, depending on the serum magnesium level, symptoms such as irregular heartbeats, decreased consciousness, respiratory depression, and cardiac arrest may occur, prompting immediate discontinuation of administration and, if necessary, incremental intravenous administration of calcium gluconate for detoxification. This medication should be diluted to below 10% concentration for slow intravenous administration, and mixing with certain medications may cause precipitation, so mixing should be avoided. Additionally, to prevent infection, the administration site and equipment must be thoroughly disinfected, and it should be used immediately after opening; any unused solution should not be reused.

Serious side effects

Conduction disorders, bradycardia, respiratory arrest due to magnesium toxicity.

Mild side effects

• Vomiting
• dry mouth
• flushing
• peripheral vasodilation
• headache
• a feeling of heaviness in the head
• tremors
• tingling
• warmth
• thirst

This medication should be stored in a sealed container to prevent air and moisture ingress, ideally at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy and prevent deterioration.

Appearance

A colorless and transparent liquid contained in a colorless and transparent glass ampule or a plastic aqueous injection container.

Package unit

50 ampules/box [(20mL/ampule)]