Hyaluronic Acid Dispo Injection (Sodium Hyaluronate) (Pre-filled)

Adult administration

Administer 25 mg of sodium hyaluronate by intra-articular injection once a week for 5 consecutive weeks into the knee joint or shoulder joint (glenohumeral joint, subacromial bursa, or bicipital tendon sheath). Adjust the number of doses as appropriate based on symptoms. This medication is administered into the knee joint under strict aseptic technique.

It is important not to use this medication in certain patients. Initially, patients who have had an allergic reaction to this medication or any of its components should not be administered this treatment. Additionally, patients with skin diseases or infections at the injection site should not use it. Caution is needed for patients with liver dysfunction or those who have had liver disease in the past, as cases of abnormal liver enzyme levels have been reported. Patients allergic to avian proteins should also not use this medication. When administering this medication, various side effects may occur. The most serious side effect may include shock reactions, so the patient should be closely monitored after administration. Allergic reactions can manifest as swelling of the face or around the eyes, rashes, hives, or itching, and treatment should be immediately stopped if these symptoms appear. The injection site may experience temporary pain, swelling, redness, warmth, severe pressure, and bruising. Symptoms such as nausea, vomiting, fever, or headache may also occur. In cases of severe arthritis or intense inflammation, this medication may worsen inflammation, thus it is advisable to administer it after the inflammation has subsided. After injection, stabilization of the injection site is encouraged, and care should be taken to prevent the medication from leaking outside the joint. Patients with rheumatoid arthritis or gout may experience temporary exacerbation of inflammation. It is advisable to avoid intense physical activity or prolonged weight-bearing activities within 48 hours after injection. The safety and efficacy of this medication have not been confirmed when used in conjunction with other intra-articular injectables, so it is safest not to combine them. Pregnant women or those who may become pregnant should use this medication cautiously, as its safety has not been established, and it should only be considered when the therapeutic benefits outweigh the risks. Furthermore, this medication can be transmitted through breast milk, so it is advisable to avoid breastfeeding during treatment. The safety of this medication in children has not been sufficiently established, so it should be administered cautiously only when necessary. Elderly patients may have decreased physical function, so special caution is required during administration. Sterile conditions must be strictly maintained during injection, and if symptoms do not improve, administration should be limited to a maximum of 5 times. If necessary, a procedure to remove excess fluid from the joint may be performed. This medication is not used for intravenous injection or ophthalmologic purposes, and care should be taken when selecting the injection needle and using the syringe due to its viscosity. When transferring the medication to the syringe, be careful to handle it gently to ensure that the solution flows well from the ampoule, and clean the area before cutting the ampoule to prevent contamination. Additionally, caution is advised as precipitate may form when mixed with certain disinfectants. This medication is for single use and any remaining medication should be discarded after opening. It is recommended to administer this medication after a local anesthetic has been injected.

Serious side effects

• Hives
• swelling
• severe allergic reactions
• shock

Mild side effects

Swelling (facial, eyelid, etc.), facial flushing, rashes, hives, itching, pain (mostly transient pain after administration), swelling, edema, redness, warmth, severe localized pressure, petechiae, nausea, vomiting, fever, headache

This medication should be stored in a sealed container to prevent air ingress, preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way can help maintain the medication's effectiveness for a longer period.

Appearance

A colorless, transparent viscous solution filled in a glass vial sealed with rubber caps at both ends (part of the pre-filled syringe system)

Package unit

2.5 mL/vial × 5, 2.5 mL/vial × 10