Kanesten Tablets (Clotrimazole)

Adult dosage

Typically, 100 mg of clotrimazole is inserted deeply into the vagina once daily for 6 consecutive nights. For short-term therapy, typically, 200 mg of clotrimazole is inserted deeply into the vagina once daily for 3 consecutive nights at bedtime.

This medication should not be used by individuals who have allergies or have experienced hypersensitivity reactions to the active ingredient or any of the excipients. While using this medication, it should not be taken concurrently with certain immunosuppressants such as tacrolimus or sirolimus. Concurrent use may elevate the blood concentrations of these medications, leading to potential side effects; therefore, periodic monitoring of blood levels under a physician’s direction is necessary. Women who are pregnant or may become pregnant should consult a doctor before using this medication. Although no specific abnormalities were found in animal studies, it should only be used during pregnancy under a physician's diagnosis and guidance, and it is advisable to avoid using insertion tools while applying the vaginal tablet. Women who are breastfeeding should also consult a physician prior to using this medication. While systemic absorption is low and the likelihood of transfer into breast milk is minimal, it is important to seek professional advice for safety considerations. If any unusual symptoms such as allergic reactions, hypotension, difficulty breathing, abdominal pain, skin rash, or abnormal vaginal discharge occur while using this medication, it should be discontinued immediately, and a doctor or pharmacist should be consulted. It is advisable not to use this medication during menstruation, and it may be necessary to seek additional treatment to ensure complete infection clearance; consultation with a professional is recommended. To prevent reinfection, it is important to maintain personal hygiene by frequently changing towels and underwear and washing them thoroughly. During the use of this medication, it is advisable to avoid tampons, vaginal cleansers, or other vaginal insertion products, and to refrain from vaginal intercourse as the partner may become infected. Care should be taken to avoid this medication coming into contact with the eyes, and it should never be ingested. If symptoms such as high fever, abdominal pain, foul-smelling discharge, or bleeding occur, a physician should be consulted immediately. While the risk of acute toxicity in case of overdose is low, if an excessive amount is accidentally taken, prompt medical attention should be sought. This medication may weaken the strength of condoms or diaphragms made of latex or rubber, so caution is needed during use. This medication is intended for vaginal use only and must not be used orally. It can only be used by children aged 12 years and older and adults. Store this medication out of reach of children, and keep it sealed in its original container. It is advisable to store it in a cool place away from direct sunlight and moisture.

Serious side effects

• Anaphylactic reaction
• angioedema
• hypersensitivity
• syncope
• hypotension
• difficulty breathing

Mild side effects

• Abdominal pain
• nausea
• rash
• urticaria (hives)
• pruritus
• vaginal peeling
• vaginal discharge
• vaginal bleeding
• discomfort in the vulva
• erythema of the vulva (red spots)

Drug interactions

Do not use this medication concurrently with oral tacrolimus.

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 25 degrees Celsius to ensure the effectiveness of the medication.

Appearance

White elongated vaginal tablet

Package unit

6 tablets/PTP