Epi Solution (Clindamycin Phosphate)

Adult administration

(Injection) For severe infections, clindamycin phosphate 600-1200 mg (potency) is administered intravenously or intramuscularly in 2-4 divided doses. For severe infections, 1200-2700 mg (potency) is given in 2-4 divided doses. In emergencies, the daily dose may be increased to 4.8 g (potency) and administered intravenously. The injection is not administered directly into the vein but is injected over at least 10-60 minutes.

Child administration

(Injection) For children (over 1 month old) with severe infections, administer 15-25 mg (potency) per kg of body weight, divided into 3-4 intravenous or intramuscular injections. For severe infections, administer 25-40 mg per kg of body weight, divided into 3-4 doses.

This medication is used for the treatment of severe infections and may sometimes cause serious colitis, which can be fatal; it should only be used when treatment with other antibiotics is difficult. If severe and persistent diarrhea, abdominal pain, or fever occurs while using this medication, discontinue immediately and consult a doctor. This drug does not penetrate well into the cerebrospinal fluid and is not suitable for the treatment of meningitis. When using the injection, care must be taken to cut the container carefully to prevent glass particle contamination, and special caution is needed for children and the elderly. Those allergic to lincomycin or clindamycin should not use this medication. Elderly individuals, debilitated patients, those with impaired liver or kidney function, those with atopic constitution or asthma, and patients with myasthenia gravis should be particularly cautious when using this medication. This drug may cause pain or numbness at the muscle injection site and thrombophlebitis with intravenous administration; therefore, attention is required in the injection method. Gastrointestinal symptoms may include diarrhea, nausea, vomiting, and abdominal pain, with severe cases potentially leading to pseudomembranous colitis. If allergic reactions such as generalized flushing, hives, or breathing difficulties occur, discontinue use immediately and seek emergency treatment. Various side effects have been reported, including liver dysfunction, renal impairment, blood disorders, neurological issues, and respiratory problems; therefore, regular check-ups are necessary during long-term administration. To prevent the occurrence of resistant bacteria, sensitivity testing should be conducted and the drug should only be used for the necessary minimum duration. It is advisable for women who are pregnant or may become pregnant and for breastfeeding women not to use this medication. The safety of this drug has not been established for children and neonates, and it should be used carefully if necessary, with regular monitoring of liver and kidney functions. The effects on driving or operating machinery are unclear, so caution is advised. In case of overdose, there is no specific antidote, and appropriate emergency treatment should be administered according to symptoms. This medication should be used as soon as possible after dissolution, and it is recommended to use it within 48 hours at room temperature during storage. Pain or cramps may occur at the injection site, and rapid intravenous administration should be avoided. When using in topical solution or gel form, skin irritation or allergic reactions can occur, so if symptoms appear, discontinue use and consult a professional. This drug has an unpleasant taste, so caution is needed when applying it around the mouth, and it should not come into contact with the eyes or damaged skin. When storing this medication, keep it out of reach of children and store it in its original container for safety.

Serious side effects

Severe colitis, colitis with blood in the stool, pseudomembranous colitis, generalized flushing, hives, breathing difficulties, chest discomfort, severe allergic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, jaundice, liver dysfunction, acute kidney failure, oliguria, proteinuria, cardiopulmonary arrest due to rapid intravenous administration, hypotension, neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura, aplastic anemia

Mild side effects

Pain, numbness, and thrombophlebitis at the muscle injection site, pseudomembranous colitis, diarrhea, loose stools, loss of appetite, nausea, vomiting, abdominal pain, esophagitis, glossitis, stomatitis, generalized flushing, hives, cyanosis, breathing difficulties, chest discomfort, hypotension, rash, erythema, measles-like rash, edema, itching, vaginitis, desquamation, and vesicular dermatitis, angioedema, penicillin allergic reactions, bad taste, metallic taste, facial flushing

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it should be stored at room temperature, between 1 and 30 degrees Celsius, rather than in extremely hot or cold places.

Appearance

Colorless topical solution with an alcohol smell

Package unit

1 bottle/box [30mL/bottle]