Promactab 500 mg (Valproate Magnesium)

Adult dose

Adults: Administer 800 ∼ 1,500 mg of magnesium valproate per day orally in 2 ∼ 3 divided doses.

This medication requires special caution in pregnant women. Pregnant women should only use this medication when there are no alternative treatment methods available, and women of childbearing potential must strictly follow effective pregnancy prevention programs. The effectiveness of this medication may be reduced when used with hormonal contraceptives that contain estrogen, so physicians should closely monitor the patient’s condition during the initiation and cessation of such medications. Patients taking antiepileptic drugs are at increased risk for suicidal thoughts or behaviors and mental health issues such as depression; thus, mood and behavioral changes should be closely monitored during treatment. For patients with impaired liver functions or at high risk for liver damage, especially in children under 3 years, this medication should be used alone with regular liver function tests. Symptoms of liver damage include fatigue, loss of appetite, abdominal pain, and if these symptoms appear, the physician must be notified immediately. This medication can occasionally cause severe pancreatitis, so if symptoms such as abdominal pain or vomiting occur, prompt medical evaluation is necessary. Regular liver function tests and blood tests should be conducted throughout treatment, and patients with bleeding tendencies should have their coagulation state monitored closely. This medication can interact with various other drugs, so if you are taking other medications, you must inform your healthcare provider, especially when using antidepressants, antibiotics, anticoagulants, etc. It is recommended not to combine alcohol or central nervous system depressants during usage, as drowsiness or sedative effects may occur; thus, driving or operating hazardous machinery should be avoided. Discontinuing this medication suddenly can worsen seizures, so when stopping, it must be tapered off gradually under a doctor’s guidance. Overdose can result in symptoms such as coma, sedation, and muscle weakness, so if suspected, immediate hospital care should be sought. When taking, do not chew or crush the tablets; they should be swallowed with sufficient water, and it is normal for white residue to be excreted, so there is no need to worry. Finally, keep this medication out of the reach of children, and do not transfer it to another container for safety.

Changes in liver function test values, severe liver damage, increased frequency of seizures, altered consciousness, drowsy state, coma, cognitive impairment, symptoms of dementia, Parkinsonism, position-related fine tremor, drowsiness, sedative effect, tremor, ataxia, headache, confusion, convulsions, excitability, hallucinations, dizziness, insomnia, anxiety, visual disturbances, nystagmus, diplopia, inability to maintain posture, phenomena of seeing spots in front of the eyes, dysarthria, sensory changes, excessive salivation, coma, hyperammonemia, impaired consciousness, emotional confusion, depression, psychosis, aggression, hyperactivity, behavioral dementia, suicidal impulses, suicidal behavior, depression, increased appetite, abnormal weight gain, abdominal pain, loss of appetite, discomfort in the upper abdomen, constipation, stomatitis, nausea, abdominal pain, vomiting, diarrhea, pancreatitis, irregular menstruation, secondary amenorrhea, polycystic ovary syndrome, breast enlargement, galactorrhea, hyperandrogenemia, thyroid dysfunction, hair loss, hair discoloration, curly hair, skin rash, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, erythematous rash, weakness, decrease in fibrinogen, decrease in coagulation factor VIII concentration, prolonged bleeding time, hyperglycinemia, anemia, increased macrocytes, pancytopenia, leukopenia, thrombocytopenia, hemolytic anemia, macrocytic anemia, agranulocytosis, decreased platelet aggregation ability, lymphocytopenia, neutropenia, petechiae, contusions, hematoma formation, genuine bleeding, pure red cell aplasia, bone marrow failure, hearing loss, tinnitus, interstitial nephritis, nocturia, Fanconi syndrome, hyperinsulinemia, decreased IGFBP-I, hypothermia, hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone, allergic reaction, angioedema, DRESS syndrome, erythema nodosum, vasculitis, brain atrophy, dementia, hematuria, thirst, malaise, epistaxis, systemic edema, localized edema, weight loss, weight gain, lupus-like syndrome, confusion, sedation, coma, myasthenia, diminished reflexes, areflexia, hypotension, miosis, cardiovascular diseases, respiratory diseases, cerebral edema, metabolic acidosis, hypokalemia, hypernatremia

This medication is sensitive to light and should be stored in a light-blocking container. Additionally, for safe storage, it is best to keep it at room temperature, between 1 to 30 degrees Celsius.

Appearance

White oval enteric-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle