Tiserin 50 mg Tablets (Levomepromazine Maleate)

Adult dose

The therapeutic dose of this medicine should be adjusted according to the patient's clinical condition, and the minimum effective dose should be administered whenever possible. Adults: 1. Psychosis The initial dose is 25∼50 mg of levomepromazine per day, administered orally in 2∼4 divided doses, and may be increased to the maximum daily dose of 150∼250 mg. Once symptoms improve, administer a maintenance dose appropriate for the patient's condition. 2. Relief of neurotic anxiety, aggression, and agitation, and pain The initial dose is 6∼25 mg of this medicine per day, administered in 2∼4 divided doses, and may be increased to 75∼100 mg. Once symptoms improve, administer a maintenance dose appropriate for the patient's condition. 3. Sleep disorders Administer 10∼25 mg of this medicine once daily at bedtime. Adjust the dose as appropriate according to symptoms.

This drug may increase mortality when used in elderly patients with dementia, so special caution is required. There is a potential increase in the risk of cerebrovascular disease, and it should be used carefully in patients at risk of stroke. There is a risk of venous thromboembolism; therefore, thromboembolic risk factors should be carefully checked and preventive measures taken before and during use. Patients with a history of allergic reactions to this drug or similar drugs, liver, kidney, or hematological abnormalities, women who are pregnant or nursing, and those with severe hypotension should not use it. Use in combination with central nervous system depressants or antihypertensive agents, or specific medications may pose risks; consultation with a physician is necessary. Elderly patients, those with cardiovascular diseases, respiratory diseases, and a history of seizures should use this drug cautiously. This drug may cause various side effects including drowsiness, dizziness, insomnia, dry mouth, constipation, weight gain, Parkinsonian symptoms, blood abnormalities, liver dysfunction, hypotension, and cardiac issues. To prevent orthostatic hypotension, patients should lie down for a period after the initial dose and any repeat doses, and should avoid driving or operating dangerous machinery if drowsiness or reduced concentration occurs. It is advisable to avoid alcohol consumption while taking this medication. Since blood abnormalities can occur, such as leukopenia, regular blood tests are necessary. Caution should be exercised when patients have heart-related issues or a family history of QT interval prolongation, or when this drug is used with other drugs that prolong the QT interval. Serious side effects such as tardive dyskinesia or neuroleptic malignant syndrome may occur, so if any abnormal symptoms appear, immediate consultation with a physician is essential. Women who are pregnant or may become pregnant, as well as nursing mothers, should not use this drug due to potential side effects on the neonate in the third trimester. Children should not be administered this drug due to a higher risk of side effects. Elderly patients should start at a lower dose and gradually increase while closely monitoring for side effects. In case of overdose, severe Parkinsonian symptoms or coma may occur, so immediate medical treatment is required.

• drowsiness
• dizziness
• confusion
• insomnia
• headache
• anxiety
• agitation
• easy irritability
• convulsions
• dry mouth

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 500 tablets/bottle