Chloroquine Tablet 400 mg (Hydroxychloroquine Sulfate)

Adult dose

Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases The initial dose is 200～400mg daily. If administering 400mg, divide the dose. Once an effect is achieved, reduce the dose to 200mg daily; if the effect is insufficient, increase the dose to 400mg daily. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. For rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, discontinue treatment if there is no improvement in symptoms after 6 months of use. When used for photosensitive diseases, administer only during periods of substantial exposure. Treatment of malaria For treatment of acute disease, administer 800mg initially, followed by 400mg 3 more times at 6∼8-hour intervals, for a total of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or Plasmodium vivax (P.falciparum, P.vivax), a single dose of 800mg may be administered. Prevention of malaria Administer 6mg/kg once weekly (usually 400mg once weekly), starting 2 weeks before exposure.

Child dose

Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. Treatment of malaria Administer 10mg/kg of chloroquine initially, followed by 5mg/kg 3 more times at 6-8-hour intervals, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. Prevention of malaria Administer 6mg/kg once weekly, starting 2 weeks before exposure. Therefore, it is preferable not to administer this medicine to children weighing less than 30∼40kg, as even 1 tablet (200mg) would exceed the appropriate dose.

This medication should not be used in certain patients. For example, individuals allergic to this drug or similar compounds, those with existing eye problems, people taking other medications that can cause vision issues, children, pregnant women, and nursing mothers should not take this medication. Patients who need to use this medication with caution include those with specific allergies, skin diseases, liver or kidney issues, severe neurological or blood disorders, etc., who should be especially careful when taking this medication. This medication can affect the eyes, possibly causing blurred vision or retinal abnormalities. If such symptoms occur, discontinue use immediately and have regular eye examinations. Skin reactions such as rashes, discoloration, and hair loss may occur, and in rare cases, severe skin reactions can develop, so skin condition should be monitored closely. Gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain may appear, which usually improve by reducing or stopping the medication. The central nervous system and muscles may also be affected, leading to fatigue, headaches, hallucinations, muscle weakness, etc., so caution is needed. It can affect the blood, leading to anemia or leukopenia, necessitating regular blood tests. It may also affect the heart, leading to arrhythmias or heart function abnormalities, so those with heart conditions should be particularly careful. Liver function may also be affected, so immediate consultation with a healthcare professional is advised if liver disease or symptoms of liver dysfunction appear. During treatment with this medication, it is important to receive ophthalmological check-ups every 3 to 6 months and regularly monitor eye health. Additionally, this medication can interact with several other drugs, so if other medications are being taken, it's essential to inform the healthcare professional, especially when combined with drugs affecting the heart or liver. Pregnant or nursing women should avoid use due to potential effects on the fetus or infant, and it is safer to discontinue breastfeeding. In cases of overdose, serious side effects may occur, so prescribed dosages must be strictly adhered to; if overdose is suspected, immediate emergency care should be sought. Finally, keep this medication out of the reach of children, and do not transfer it to another container.

Visual disturbance, retinal abnormalities, decreased corneal sensitivity, corneal opacity, pigmentary changes, visual impairment, halos, glare, skin rash, hives, skin and mucosal pigmentation changes, hair depigmentation, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, photosensitivity reaction, exfoliative dermatitis, Sweet's syndrome, severe cutaneous adverse reactions, acute generalized exanthematous pustulosis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, muscle weakness, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neurotoxic reaction, emotional changes, nightmares, tinnitus, dizziness, hearing loss, unstable emotional changes, psychosis, seizures, skeletal muscle myopathy, neuromuscular disease, sensory changes, decreased tendon reflex, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, cardiomyopathy, biventricular hypertrophy, conduction abnormalities, abnormal liver function test results, acute hepatic failure, hepatic cell injury, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant hepatic failure, depression, hallucinations, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, lethargy

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. Additionally, to maintain the drug's effectiveness, it should be stored at room temperature, between 1°C and 30°C.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle (military supply: 50 tablets/bottle, 100 tablets/bottle)