Refra Tablets (Levosulpiride)

Adult dose

Adults: Administer 25 mg of levosulpiride orally per dose 3 times daily before meals.

This medicine should not be used in women who are pregnant or may become pregnant, and in women who are breastfeeding. Do not administer to patients with gastrointestinal bleeding, mechanical obstruction, or perforation. Additionally, it should not be given to patients with certain tumors known as chromaffin cell tumors as it may cause hypertension. Patients who have an allergic reaction to this medication or who cannot tolerate it should not use it. It is also contraindicated in patients with epilepsy, certain stages of mania, or bipolar disorder. Women with malignant diseases related to the breast or certain congenital lactose degradation disorders should not use this medication. Careful use is required in patients with hypertension, children, and the elderly, especially children, as they are more likely to experience side effects and may require dose adjustments. During treatment, hormonal-related side effects such as amenorrhea, galactorrhea, and gynecomastia may occur, so symptoms should be closely monitored. Furthermore, neurological side effects such as tremors, tongue twisting, and agitation may rarely occur, and if such symptoms arise, the medication should be stopped immediately. Long-term use may lead to extrapyramidal symptoms such as involuntary movements around the mouth, so caution is needed. Gastrointestinal side effects may include dry mouth, heartburn, nausea, vomiting, diarrhea, constipation, etc. Cardiac-related side effects such as hypertension or arrhythmias may also occur, hence caution is advised. Rarely, skin rashes or swelling may occur, as well as symptoms like flushing, fatigue, insomnia, drowsiness, dizziness, staggering, erectile dysfunction, etc. It is advisable to avoid activities requiring concentration, such as driving or operating machinery, during the use of this medication. Additionally, this medication may interact with other drugs, so consultation with a doctor or pharmacist is essential, especially when using it with anticholinergics, analgesics, certain cardiac medications, and psychiatric drugs. Women who are pregnant or breastfeeding should not take this medication, and elderly patients should have their doses and intervals adjusted as kidney function may be impaired and the medication can remain in the body longer. This medication may pose risks of hormonal abnormalities or tumor development when used in high doses for a long duration, so it should be used strictly according to a physician's instructions.

• amenorrhea
• galactorrhea
• gynecomastia
• tremor
• tongue twisting
• anxiety
• involuntary movements around the mouth
• thirst
• heartburn
• nausea

This medication should be stored in a tightly closed container to prevent exposure to air or moisture and must be kept at a cool room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication for longer.

Appearance

White round tablets.

Package unit

30 tablets/bottle, 300 tablets/bottle