Tacosil

Adult use

1. Dosage: Use the drug as is, or cut into an appropriate size (1-2 cm larger than the wound area) with sterile scissors as needed. 2. Directions for Use: 1) Clean the wound area before application (remove all blood, antiseptic, and other bodily fluids thoroughly). 2) Apply the side coated with the medication (yellow side) to the wound area and press with a saline-soaked glove or soaked tampon (gauze) for 3 to 5 minutes.

This medication is derived from human blood plasma, and there is an inherent risk of infections from viruses or other infectious agents that cannot be completely eliminated. Therefore, patients with hemophilia or those with severely weakened immune systems should receive appropriate vaccinations, such as hepatitis A vaccine, and physicians should regularly check for infections during its use. This drug is intended for topical use only and must not be injected intravenously, as it may lead to serious complications such as thrombosis or vascular embolism. Safety data regarding the use of this drug in gastrointestinal surgery is insufficient, so caution is required. This drug contains proteins extracted from horses, and individuals who are allergic to horse-derived components or have previously used similar products should not use it. People with severe liver dysfunction or blood coagulation disorders need careful consideration before using this medication. Adverse effects such as shock, rash, liver dysfunction, changes in blood cell counts, etc. may occur, so any unusual symptoms should be reported to healthcare professionals immediately. Since this drug contains components derived from human blood, the risk of infection cannot be completely eliminated, and its use should be carefully considered against the necessity for treatment and minimized accordingly. Additionally, it is safer not to use this drug in conjunction with other coagulants or antithrombotic agents due to the risk of thrombosis. Women who are pregnant or breastfeeding should consult a physician before using this drug, as it may pose risks to the fetus or newborn. Safety in children has not been sufficiently established, thus special caution is advised when using this medication in pediatric patients. Care should be taken to ensure that the drug does not get on surgical gloves or instruments, any unused portion after opening should be discarded, and the packaging should be checked for damage before use. After use, patients should closely observe for adverse reactions and keep a record to aid in future management.

Serious side effects

• Hives
• angioedema
• shock
• anaphylactic shock
• hypersensitivity reactions
• jaundice
• liver abnormalities
• thrombosis
• respiratory distress

Mild side effects

Rash, eosinophilia, leukocytosis, liver dysfunction, elevated AST, elevated ALT, elevated LDH, antibody generation against fibrin adhesive/coagulant components, fever, elevated CRP, vomiting, headache, hematoma, wound dehiscence, formation of adhesions, foreign body reaction, formation of abscesses, transient oropharyngeal spasms, foreign body granuloma

This drug should be stored in a cool place below 25 degrees Celsius. Excessively high temperatures may reduce the effectiveness of the medication, so it should be kept out of direct sunlight and in a place that maintains room temperature.

Appearance

White sponge with yellow medication coated on one side

Package unit

9.5cm x 4.8cm: 1 piece, 4.8cm x 4.8cm: 2 pieces, 3.0cm x 2.5cm: 1 piece, pre-rolled (4.8cm x 4.8cm): 1 piece