Mg Sulfate Injection 10% (Magnesium Sulfate Hydrate)

Adult administration

Hypomagnesemia seizures: 1 to 2 g of magnesium sulfate is administered intravenously (4.05 to 8.1 mmol). Eclampsia seizures: 4 to 5 g of this medication is injected intravenously over 10 minutes (16.2 to 20.25 mmol). Prevention of uterine contractions: An initial dose of 4 g of this medication is administered intravenously (16.2 mmol). An additional 1 g may be given thereafter. Electrolyte supplementation (hypomagnesemia):

Child administration

The safety of this medication has not been tested.

This medication is a glass ampoule injection, so great care must be taken when opening the container to avoid the introduction of glass fragments. Extra caution is required when using it for children and the elderly. This medication should not be used in patients with poor kidney function, those in a comatose state, patients with elevated magnesium levels, patients with cardiac conduction disorders, or patients with myasthenia gravis. It should be administered carefully to children with intestinal parasitic infections or patients with heart disease. This medication may cause gastrointestinal symptoms such as vomiting or dry mouth, and rarely cardiac conduction issues or bradycardia may occur. Symptoms of autonomic nervous system involvement, including headache, dizziness, tremors, and tingling, may also appear. In case of overdose, magnesium toxicity can lead to sensations of heat, thirst, low blood pressure, central nervous system depression, suppression of heart rhythm, and respiratory paralysis, requiring immediate treatment with calcium supplements. Caution is advised when used in combination with barbiturates, narcotics, and general anesthetics as they may enhance central nervous system depression. Additionally, taking this medication with iron supplements, certain antibiotics, or sodium fluoride may reduce absorption, so be cautious when taking them together. It can be used in pregnant women for treating eclampsia, but it may affect the fetus with lowered muscle tone, decreased reflexes, and hypotension, so the fetal condition must be closely monitored. During delivery, there is a risk of respiratory depression in the newborn, so it is advisable not to use it within 2 hours after delivery. Long-term use during pregnancy may affect the fetus's bones, requiring careful monitoring of the newborn's calcium and magnesium levels. For lactating women, the safety of this medication has not been established, so it is advisable to avoid use unless absolutely necessary. Elderly individuals may have reduced bodily functions, so it is crucial to administer it slowly and at lower dosages. Serious side effects may occur from overdose, so treatment should be interrupted immediately and, if necessary, detoxification treatment with calcium gluconate injection should be provided. When administered intravenously, the concentration should be reduced to below 10% and infused slowly; it is safest not to mix it with other medications to prevent precipitation. To prevent infection, the injection site and instruments should be thoroughly disinfected, and any remaining solution after opening should not be reused.

Serious side effects

• Conduction disorders
• bradycardia
• respiratory paralysis
• cardiac arrest

Mild side effects

• Vomiting
• dry mouth
• flushed skin
• peripheral vasodilation
• headache
• heaviness in the head
• tremors
• tingling
• warmth
• thirst

This medication should be stored in a sealed container that prevents air from entering, at temperatures between 1 and 30 degrees Celsius. This will help maintain the medication's efficacy and ensure safe use.

Appearance

Colorless liquid in a colorless ampoule or transparent plastic (polypropylene, polyethylene) container

Package unit

For domestic use - 5 milliliters/ampoule [×20 ampoules], for domestic use - 5 milliliters/ampoule [×25 ampoules], for domestic use - 20 milliliters/ampoule [×50 plastic ampoules], for export - 20 milliliters/ampoule [×20 plastic ampoules], for export - 20 milliliters/ampoule [×40 plastic ampoules]