Miranaproxen Sodium Tablet

Adult dose

1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis Adult dosage is 275-550mg of naproxen sodium, taken orally twice a day (every 12 hours). 2. Acute gout Initially, 825mg of naproxen sodium is taken orally, followed by 275mg every 8 hours until the attack subsides. 3. Skeletal muscle disorders, postoperative pain, pain after tooth extraction, dysmenorrhea, tendinitis, bursitis Initially, 550mg of naproxen sodium is taken orally, followed by 275mg every 6-8 hours. The total daily dose should not exceed 1350mg. 4. Migraine Initially, 825mg of naproxen sodium is taken orally. Additional 275-550mg may be taken within 30 minutes after the initial dose if necessary, but the total daily dose should not exceed 1350mg. Adjust dosage as appropriate based on age and symptoms.

This medication may cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic beverages daily; therefore, consultation with a physician or pharmacist is essential. As a non-steroidal anti-inflammatory drug, it can increase the risk of cardiovascular diseases, so patients with heart disease or risk factors should be particularly cautious. This medication may cause serious gastrointestinal adverse reactions such as gastrointestinal bleeding, ulcers, and perforation; thus, elderly patients or those with a history of gastrointestinal diseases should be especially careful. It should not be used in patients with peptic ulcers, severe blood abnormalities, severely impaired liver, heart, or kidney function, hypertension, or hypersensitivity to this medication. Patients with a history of peptic ulcers or bleeding tendencies, liver damage, kidney issues, heart function impairments, hypertension, asthma, or autoimmune diseases should use this medication with caution. If any abnormal symptoms such as allergic reactions, gastrointestinal bleeding, blood abnormalities, liver or kidney function abnormalities, or skin rashes occur during treatment, the medication should be discontinued immediately, and medical advice should be sought. Taking this medication with other non-steroidal anti-inflammatory drugs may increase the risk of side effects, so co-administration is not recommended. Additionally, there may be interactions with certain antihypertensives, diuretics, anticoagulants, and lithium; thus, it is important to inform of any other medications being taken. It should be avoided during late pregnancy, as it may harm the fetus, and women who may become pregnant should use it cautiously. It is not recommended for breastfeeding women, as this medication may be transmitted through breast milk and affect the newborn. The safety of this medication has not been established in children, particularly infants under 2 years of age, so its use is not advised. Elderly patients are at a higher risk of side effects such as gastrointestinal bleeding and should take the minimum dosage with caution. In cases of overdose, symptoms such as drowsiness, indigestion, and vomiting may occur, necessitating immediate medical attention. This medication should be stored out of reach of children, and care should be taken not to transfer it to other containers, as this may affect the quality.

Serious side effects

• Hives
• severe swelling (edema)
• chest tightness
• difficulty breathing
• cold sweat
• pallor
• vomiting blood
• gastrointestinal bleeding
• peptic ulcers
• perforation

Mild side effects

• Itching
• rash
• gastrointestinal discomfort
• stomach pain
• abdominal pain
• nausea
• vomiting
• loss of appetite
• dyspepsia
• heartburn

Drug interactions

This medication should not be taken with other non-steroidal anti-inflammatory drugs, naproxen derivatives, aspirin, or high doses of methotrexate. Do not co-administer with hydantoin anticonvulsants, sulfonamides, sulfonylurea hypoglycemic agents, propranolol and other beta-blockers, ACE inhibitors (such as captopril), loop diuretics, thiazide diuretics, probenecid, lithium, low-dose methotrexate, warfarin or other coumarin anticoagulants.

This medication should be stored in a tightly sealed container to prevent air or moisture exposure. It is best to maintain storage at room temperature between 1°C to 30°C. Doing so will help maintain the medication's effectiveness for a longer period.

Appearance

It is a blue oval film-coated tablet.

Package unit

10 tablets/pack (2 tablets/pack × 5), 10 tablets/PTP