Zophyrin Controlled Release Tablet (Sulfasalazine)

Adult dose

1. Rheumatoid arthritis 1) Initial dose: The usual adult dose is 500 mg of sulfasalazine orally once daily. 2) Maintenance dose: Administer 500 mg of this drug per dose 2～4 times daily. Depending on improvement in symptoms with the initial dose, increase the total daily dose by 500 mg each week to reach the maintenance dose. 2. Ulcerative colitis The usual adult dose is 1 g of this drug per dose 4～6 times daily; as symptoms improve, administer 500 mg per dose 4 times daily. Adjust the dose appropriately according to age and symptoms.

This medication should not be used in patients with a history of specific allergic reactions, in pregnant or breastfeeding women, or in infants under 2 years old. It should also be avoided in patients with severe liver or kidney dysfunction, blood-related diseases, and those with certain genetic deficiencies. Regular blood tests, liver function tests, and kidney function tests are important to detect adverse reactions early when using this medication. During the first 3 to 6 months, adverse reactions may occur frequently, so it is essential to observe patients closely. Various side effects can occur, including skin rash, fever, nausea, vomiting, abdominal pain, neurological symptoms, hepatitis, and nephritis, so if these symptoms occur, consult a healthcare professional immediately. This medication may interact with other drugs, so it is essential to inform the healthcare provider about any other medications being taken. Pregnant women or those who may become pregnant, as well as nursing mothers, should not use this medication, and it should not be administered to newborns or low-birthweight infants. Older adults may have a higher risk of side effects, so treatment should begin with a lower dose and the condition should be monitored closely. In case of overdose, symptoms such as vomiting, gastrointestinal disturbances, and neurological symptoms may occur, and it is vital to visit a medical facility promptly for appropriate treatment. This medication is enteric-coated, so do not chew or crush the tablets but swallow them whole. It is important to maintain adequate fluid intake to prevent crystalluria and stone formation. If severe skin adverse reactions or serious allergic symptoms occur, discontinue use immediately and consult a healthcare professional.

Aplastic anemia, agranulocytosis, leukopenia, macrocytic anemia, purpura, hemolytic anemia, thrombocytopenia, hypoprothrombinemia, methemoglobinemia, congenital neutropenia, disseminated intravascular coagulation, immunoglobulin deficiency, atypical lymphocytes, eosinophilia, Heinz body anemia, myelodysplastic syndrome, pancytopenia, hepatitis, pancreatitis, hemorrhagic diarrhea, folate malabsorption, digoxin absorption disorder, gastritis, diarrhea, enterocolitis, abdominal pain, loss of appetite, nausea, vomiting, peptic ulcer, sigmoid colon perforation, gastric pain, stomatitis, upper gastric discomfort, constipation, abdominal distension, cheilitis, glossitis, dry mouth, membranous colitis, exacerbation of ulcerative colitis, transverse myelitis, tremor, meningitis, transient lesions of the posterior spine, paralysis syndrome, Guillain-Barré syndrome, peripheral neuropathy, depression, dizziness, hearing loss, insomnia, ataxia, hallucinations, tinnitus, drowsiness, headache, consciousness disturbance, convulsions, encephalopathy, amnesia, fever, rash, erythema, conjunctivitis, mucocutaneous syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, erythema multiforme, systemic lupus erythematosus, hair loss, exfoliative dermatitis, itching, urticaria, lichen planus, cyanosis, hepatitis, liver dysfunction, jaundice, hepatic necrosis, fulminant hepatitis, polyuria, anuria, nephritis, hematuria, crystalluria, proteinuria, toxic nephritis, acute renal failure, nephrotic syndrome, interstitial nephritis, urinary stones, edema, elevated BUN, swelling, diabetes, urinary tract infection, hemolytic uremic syndrome, pyelonephritis, rash, hypersensitivity syndrome, infectious mononucleosis, facial flushing, photosensitive reaction, serum sickness, anaphylaxis, vasculitis, pleuritis, myocarditis, allergic myocarditis, nodular polyarteritis, varioliform nodular psoriasis, rhabdomyolysis, arthralgia, periorbital edema, angioedema, lymphadenopathy, interstitial pneumonia, drug-induced pneumonia, eosinophilic pulmonary infiltrates, fibrosing alveolitis, urine discoloration, skin depigmentation, lethargy, taste alterations, olfactory abnormalities, palpitations, myalgia, heartburn, goiter formation, diuresis, hypoglycemia, DRESS syndrome, nausea, vomiting, gastrointestinal disorders, neuropsychiatric symptoms, strabismus, convulsions, drowsiness, headache, dizziness, transient myopia, diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is also recommended to store the medication at room temperature, preferably between 1 to 30 degrees Celsius, avoiding extremes of temperature.

Appearance

Yellow enteric-coated tablet

Package unit

[For domestic use] 30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle [For export] 30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle, 50,000 tablets (Drum/bulk)