Zanideep Tablets (Lercanidipine Hydrochloride)

Adult dose

Lercanidipine Hydrochloride 5 to 10 mg orally once daily, at least 15 minutes before meals. The dose may be increased up to 20 mg based on the patient's symptoms. Dose adjustments should be gradual as the maximum antihypertensive effect typically takes about 2 weeks to become apparent. Caution is required when starting treatment in elderly patients. Patients with liver or kidney impairment require special attention during initiation, and doses may be increased to 20 mg daily.

This medicine should not be used in certain patients. For example, patients with allergies to this drug or similar medications, pregnant or breastfeeding women, patients with impaired blood flow from the left ventricle, untreated heart failure patients, patients with unstable angina, patients with severe liver or kidney dysfunction, patients who have recently experienced a myocardial infarction, patients undergoing dialysis, children and adolescents under 18, and patients with genetic issues such as lactose intolerance should not take this medication. Furthermore, care should be taken when prescribing this medication to some patients. For instance, those with abnormalities in cardiac pacemakers, left ventricular functional issues, those with ischemic heart disease, patients with mild liver or kidney impairment, those with a history of angina, individuals who frequently consume alcohol, and elderly patients should use this medication cautiously. While taking this medicine, various side effects may occur. Symptoms may include facial flushing, body swelling, rapid heartbeat, low blood pressure, headaches, dizziness, fatigue, indigestion, nausea, abdominal pain, diarrhea, and there may be liver function abnormalities, thus requiring regular monitoring of liver condition. Rarely, symptoms like oral swelling, skin rashes, and muscle pain may also occur. Discontinuation of this drug should be done gradually to avoid aggravating symptoms, and caution is necessary when driving or operating machinery due to dizziness or drowsiness. Additionally, as this drug is metabolized in the liver, it can interact with certain medications affecting its efficacy. Therefore, care should be taken when using it in combination with specific antifungals, antibiotics, anticonvulsants, and immunosuppressants, and it should be avoided with grapefruit juice as it may increase blood concentration. Alcohol should also be avoided as it can amplify the blood pressure-lowering effect. Pregnant or breastfeeding women should not take this medication, and it is not for use by children or adolescents under 18 years old. Special care is needed when initiating treatment in elderly patients. In case of overdose, blood pressure may drop too low and heart rhythms may be affected, requiring immediate medical assistance and cardiovascular monitoring for at least 24 hours. Lastly, this medicine should be kept out of the reach of children, and it is advisable not to transfer it to another container.

Serious side effects

Cold sweats

Mild side effects

• Facial flushing
• peripheral edema
• palpitations
• tachycardia
• hypotension
• chest pain
• headache
• dizziness
• weakness
• fatigue

This medicine should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature to safely preserve the drug's efficacy.

Appearance

Yellow round film-coated tablets

Package unit

100 tablets (10 tablets/PTP x 10), 500 tablets/bottle