Hyuons Pentoxifylline Injection

Adult dosage

1. Intravenous injection: Adults receive 100mg of pentoxifylline per day. With the patient lying down, inject slowly intravenously over at least 5 minutes. To assess the patient's individual response, it is preferable to dilute the initial dose in normal saline for injection. 2. Intravenous infusion: Initially, mix 100mg per day in 250~500ml of infusion solution (normal saline for injection, 5% fructose injection, etc.) and administer by intravenous infusion over 90~180 minutes. Starting the following day, increase the daily dose by 50mg each day until it reaches 300mg. In cases of severe circulatory impairment, administer twice daily. 3. As an adjunct to intravenous injection or infusion, 100~200mg of tablets may be administered. After symptoms improve, treatment may be continued by oral administration. Adjust the dose appropriately according to age and symptoms.

This drug, when used as an ampoule injection, may have glass fragments when cutting the container, so extreme caution is necessary during use. Special care is required when administering to children or the elderly. This drug should not be used in individuals allergic to this medication or other medications in the methylxanthine class, those with acute myocardial infarction, massive bleeding, extensive retinal hemorrhage, or those currently taking ketorolac. It should be used cautiously in patients with severe cardiac arrhythmias or low blood pressure, significantly impaired renal function, severe liver dysfunction, those at high risk of bleeding, and cardiovascular patients at risk of rapid blood pressure drops. When using this medication, allergic reactions such as itching, skin rash, and hives may occur, and in severe cases, it can lead to serious reactions such as difficulty breathing or shock. If these symptoms appear, administration should be stopped immediately, and a doctor should be consulted. Additionally, fast heartbeats or angina symptoms may occur, liver function test values may increase, and patients with bleeding tendencies may experience skin or mucosal, gastrointestinal bleeding. Neurological symptoms such as dizziness, headache, anxiety, and sleep disturbances may also occur. High-dose administration may frequently lead to fever, gastric discomfort, nausea, vomiting, and diarrhea, and heart arrhythmias may occur, thus the rate of administration and dosage should be carefully adjusted. For patients with low blood pressure or cardiovascular instability, starting with a small dose and gradually increasing is recommended, and heart failure patients should use medications to assist cardiac function alongside. In cases of severe arteriosclerosis, injection administration should be avoided. The risk of bleeding may increase when this drug is used with anticoagulants or platelet aggregation inhibitors, and diabetic patients should closely monitor their blood sugar levels. Caution is also needed when used with antihypertensive drugs, as it may cause blood pressure to drop too low. If used with theophylline, the level of theophylline may increase, leading to exacerbated side effects, and it should not be used in conjunction with ketorolac due to increased risk of bleeding. Safety in pregnant women has not been sufficiently established, so it is advisable not to use this medication. This medication may be excreted in breast milk, so nursing mothers should also avoid use. There is insufficient experience with the use in infants, so it is principle not to administer it to children. Elderly patients may have reduced physical function, so they should be monitored carefully while using this medication.

• pruritus
• skin redness
• urticaria
• angioedema
• bronchospasm
• shock
• tachycardia
• angina
• angina pectoris
• hypotension

This medication is sensitive to light and should be stored in a container that does not allow light exposure. It should also be kept at a temperature between 1 and 30 degrees Celsius. It is best to avoid extremely hot or cold places.

Appearance

Brown ampoule injection containing a colorless liquid

Package unit

5mL X 10 ampoules