Orphils Extended-Release Tablets 150mg (Sodium Valproate)

Adult dose

Adults: Administer an initial dose of 5-10㎎ of sodium valproate per ㎏ of body weight orally, increasing by 5㎎ every 4-7 days. The maintenance daily dose for adults is 20㎎ per ㎏ of body weight. Adjust the dose as appropriate according to age and symptoms.

Child dose

The daily dose for children is 20-30㎎ per ㎏ of body weight.

This medication should not be administered to pregnant women except in special cases. Women who may become pregnant must strictly adhere to a pregnancy prevention program; otherwise, they should not take this medication. When used in conjunction with hormonal contraceptives containing estrogen, the concentration of this medication in the blood may decrease, which can reduce its effectiveness. Physicians should closely monitor the patient's condition when starting or stopping such medications. Patients taking antiepileptic drugs may experience changes in mental health such as suicidal thoughts or behaviors and depression, so those taking this medication should be carefully monitored for these symptoms. Serious side effects such as liver damage and pancreatitis can occur rarely, so regular monitoring of liver function and patient symptoms is particularly important during the first six months of treatment. This medication should be used cautiously as a single agent in children, especially in infants under three years old, and co-administration with salicylate derivatives should be avoided. This medication may affect blood coagulation, so caution is needed in patients at risk of bleeding, and blood tests should be performed before surgery to confirm their condition. Due to central nervous system depressant effects, drowsiness or sedation may occur, so it is advisable to avoid driving or operating dangerous machinery while taking this medication. In case of overdose, symptoms such as coma, confusion, and myasthenia may occur, so the prescribed dosage must be strictly adhered to, and immediate consultation with medical personnel should be sought if any abnormal symptoms arise. There are many interactions with this medication and other drugs, so patients taking other medications should consult with their physician or pharmacist, especially when taking antibiotics, anticoagulants, or antidepressants, as caution is required. Women planning to become pregnant or who are pregnant should consult a specialist before taking this medication and should use effective contraception. Male patients should avoid donating sperm during and for three months after taking this medication; if planning for pregnancy, they should consult with their physician. Caution is necessary for dosing and regular checking when this medication is administered to children, adolescents, and the elderly. When taking this medication, do not crush or chew it, and take it with plenty of water, as white residue may appear in the stool. This medication should be kept out of reach of children and should not be transferred to other containers.

Changes in liver function tests, severe liver damage, increased seizure frequency, altered consciousness, somnolence, comatose state, cognitive impairment, symptoms of dementia, Parkinsonism, postural tremors, drowsiness, sedative effect, tremor, ataxia, headache, confusion, convulsions, hypersomnia, hallucinations, dizziness, insomnia, anxiety, visual disturbances, nystagmus, diplopia, inability to maintain fixed positions, seeing spots in front of the eyes, dysarthria, sensory changes, excessive salivation, coma, hyperammonemia, consciousness disorders, emotional disturbance, depression, psychosis, aggressiveness, hyperactivity, behavioral dementia, increased appetite, abnormal weight gain, abdominal pain, loss of appetite, discomfort in the upper abdomen, constipation, stomatitis, nausea, abdominal pain, vomiting, diarrhea, pancreatitis, irregular menstruation, secondary amenorrhea, polycystic ovary syndrome, cardiomegaly, galactorrhea, hyperandrogenemia, hair loss, hair discoloration, curly hair, skin rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthematous erythema, muscle weakness, decreased fibrinogen, decreased coagulation factor VIII concentration, prolonged bleeding time, hyperglycinemia, anemia, macrocytosis, pancytopenia, leukopenia, thrombocytopenia, hemolytic anemia, macrocytic anemia, agranulocytosis, eosinophilia, decreased platelet aggregation, lymphopenia, neutropenia, petechiae, contusions, hematoma formation, true bleeding, pure red cell aplasia, bone marrow failure, hearing loss, tinnitus, interstitial nephritis, nocturia, Fanconi syndrome, hyperinsulinemia, decreased IGFBP-I, hypothermia, hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, allergic reaction, angioedema, DRESS syndrome, erythema nodosum, vasculitis, allergic reaction, cerebral atrophy, dementia, hematuria, polydipsia, malaise, epistaxis, generalized edema, localized edema, weight loss, weight gain, lupus-like syndrome, confusion, sedation, coma, myasthenia, reduced reflexes, areflexia, hypotension, miosis, cardiovascular diseases, respiratory diseases, cerebral edema, metabolic acidosis, hypokalemia, hypernatremia, abnormal neurological response, behavioral changes, seizures

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it is best to store it away from direct sunlight and at room temperature. Proper storage will help maintain the medication's effectiveness and ensure safe usage.

Appearance

White, round, film-coated extended-release tablets

Package unit

30 tablets, 500 tablets/bottle