Genasid Dry Syrup 800 mg/5 mL (Acyclovir)

Adult dosage

1. Treatment of herpes simplex virus infections: administer 200 mg 5 times daily at 4-hour intervals for 5 days; for severe primary infections, treatment may be extended 2. Prevention of herpes simplex infections in immunocompetent patients: may administer 200 mg 4 times daily at approximately 6-hour intervals or 400 mg twice daily at 12-hour intervals 3. Prevention of herpes simplex infections in immunocompromised patients: administer 200 mg 4 times daily at approximately 6-hour intervals

Children's dosage

1. Treatment of herpes simplex infections and prevention in immunocompromised patients: same as adults for children over 2 years; for children under 2 years, administer 1/2 the adult dose 2. Treatment of chickenpox in children over 2 years: 20 mg per kg once

This medicine should not be used in patients who have had an allergic reaction to this drug or any of its components, including valacyclovir. Patients with poor renal function may be prone to neurological adverse reactions while taking this medicine, so caution is advised. Patients with impaired liver function may be at risk of further worsening liver function when taking this medicine, so it should be used cautiously. Infants and children should use this medicine with greater caution, and it should only be given in the minimum effective dose when necessary. Elderly patients may have diminished kidney function, leading to prolonged drug retention in the body, increasing the risk of adverse reactions, so dosage and administration intervals should be adjusted, and adequate hydration is necessary. During this treatment, rare occurrences of anaphylactic shock or severe allergic reactions can arise; thus, if symptoms such as low blood pressure, difficulty breathing, or chest tightness occur, the medication should be discontinued immediately and medical attention sought. Skin rash, fever, blisters, hives may occur, and severe skin conditions such as Stevens-Johnson syndrome or Lyell syndrome may present as symptoms. Neuropsychiatric symptoms like confusion, drowsiness, tremors, seizures, hallucinations, anxiety, insomnia, etc., can occur, particularly more frequently in elderly patients or those with renal impairment. Deteriorating kidney function can lead to renal failure, hematuria, and proteinuria, so caution is needed. Hematological abnormalities such as leukopenia, anemia, bleeding, and purpura may appear, so consult a doctor immediately if symptoms occur. Liver function may worsen, leading to hepatitis and jaundice symptoms; inform your doctor if there are existing liver health issues. Gastrointestinal symptoms like nausea, vomiting, abdominal pain, and diarrhea may appear; if these symptoms are severe, discontinue use and consult a doctor. This medicine should be changed to another treatment if symptoms do not improve or worsen, especially for the treatment of herpes simplex, chickenpox, and herpes zoster, the early administration of which is most effective. Patients with compromised immune functions may need to consider intravenous alternatives instead of this medicine. Adequate hydration is required during this treatment to prevent dehydration and reduce the risk of renal toxicity. In the treatment of recurrent genital herpes, the need to continue treatment should be reviewed after one year of administration. This medication may cause consciousness disturbances, so caution should be taken when driving or operating dangerous machinery, and those with renal impairment should be particularly careful. There may be interactions if this medicine is taken with others, so inform your doctor or pharmacist if you are taking probenecid, cimetidine, theophylline, or mycophenolate mofetil. Pregnant women or those who could become pregnant should carefully consider the necessity and risks of treatment with this medicine as it may affect the fetus. Components of this medication can be transmitted through breast milk, so it is advisable to discontinue breastfeeding during treatment. Infants and children should use this medicine minimally, particularly in neonates or low birth weight infants, where safety has not been established and should be administered cautiously. Elderly patients should adjust dosage and administration intervals due to prolonged drug retention related to decreased renal function, and should drink plenty of water. Overdosage may lead to agitation, stupor, seizures, and renal failure, in which case serum drug levels should be measured and treatment such as dialysis may be required as necessary. There have been reports of mutagenicity with high doses of this medicine; however, it is known that routine recommended doses do not affect sperm count.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, anaphylactic shock, anaphylactoid reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes (mouth/eyes), Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, jaundice (yellowing of skin or eyes)

Mild side effects

• Photosensitivity reactions
• fixed drug eruptions
• rash
• fever
• blisters
• alopecia
• erythema multiforme
• consciousness disturbances
• spatial disorientation
• concentration disturbances

This medication can be sensitive to air and moisture, so it should be stored in a tightly closed container. When storing, avoid direct sunlight and keep it at room temperature.

Appearance

Light pink powder for reconstitution

Package unit

20 grams (suspension of 30 mL), 320 grams (suspension of 480 mL)