Dicodisarbangjeong (Dihydrocodone Tartrate)

Adult dose

Adults and adolescents aged 13 years and older: Take 60 to 120 mg every 12 hours. The tablet should be swallowed whole without chewing.

Child dose

Not to be administered to children under 12 years of age.

This medication may pose a risk of severe respiratory depression; therefore, it should not be used in obese patients under 18 years of age or in patients with obstructive sleep apnea syndrome or severe lung disease. Additionally, it should be used with caution in combination with central nervous system depressants such as narcotics, benzodiazepines, and alcohol, as this may lead to severe sedation, respiratory depression, coma, or even death. This medication should never be administered to patients with hypersensitivity to it, or those with severe respiratory depression, paralytic ileus, increased intracranial pressure, acute alcohol intoxication, or persistent asthma attacks. Patients with lactose intolerance, acute or chronic pancreatitis, or those on MAO inhibitors should also not use this medication. Particular caution is advised for asthma patients, the elderly, those with hypothyroidism, weakened liver or kidney function, a history of drug dependence or alcohol addiction, gallbladder disease or benign prostatic hyperplasia. Similarly, patients with adrenal function impairment, constipation, or pulmonary heart disease should be monitored closely. This medication may lead to dependence when taken for extended periods; therefore, the dosage should be gradually reduced upon discontinuation, and withdrawal symptoms should be carefully observed. Respiratory depression symptoms may occur, so respiratory status should be closely monitored and immediate appropriate treatment should be provided in case of any unusual reactions. Various side effects such as constipation, nausea, vomiting, headache, drowsiness, dizziness, hallucinations, rash, urinary disturbances, and more may occur, so attention is warranted. Driving or operating dangerous machinery should be avoided due to potential drowsiness or dizziness. This medication may exacerbate side effects when taken with other central nervous system depressants, thus dosages should be adjusted and patient status should be closely monitored when taken in combination. Women who are pregnant or may become pregnant should avoid this medication, and extra caution is required around childbirth due to risks of respiratory depression or withdrawal symptoms in neonates. In cases of nursing, discontinuation of breastfeeding is recommended. Elderly patients should receive careful dosage adjustments due to reduced bodily functions and increased risk of respiratory depression. In cases of overdose, it is crucial to seek immediate medical attention for proper emergency care including inducing vomiting, gastric lavage, and administering activated charcoal. If respiratory depression or reduced consciousness occurs, swift treatment such as airway management, oxygen administration, and assisted ventilation is necessary, and continuous monitoring is required even after narcotic antagonist administration. In cases of severe hypotension or cardiac dysfunction, appropriate intravenous fluid therapy and cardiac treatment should be initiated.

Serious side effects

• Hives
• difficulty breathing
• slow breathing
• irregular breathing
• apnea
• respiratory depression
• severe swelling
• dependence
• confusion
• memory loss

Mild side effects

Constipation, nausea, vomiting, biliary colic, thirst, abdominal pain, urinary retention, ureteral spasm, headache, drowsiness, mood changes, dizziness, hallucinations, euphoria, itching, rash, blurred vision, sweating, decreased libido, sensory disturbances, yawning, sneezing, tearing, excessive sweating, diarrhea, pupil dilation, insomnia, anxiety, delirium, tremors, pain in muscles and joints throughout the body, palpitations

This medication may be sensitive to air or moisture; therefore, it must be stored in a tightly closed container. Additionally, it is important to keep the medication in a cool place below 25 degrees Celsius to maintain its efficacy.

Appearance

White or whitish rectangular prolonged-release tablet

Package unit

100 tablets (10 tablets/PTP X 10)