Pentasa Suppository (Mesalazine)

Adult use

Usually, adults insert 1 suppository into the rectum once daily. As this medicine is a suppository, it is preferable to have a bowel movement before administration. Place the enclosed rubber finger cot on a finger and insert the suppository deep into the anus until resistance is felt and then subsides. It may be moistened with water to facilitate insertion. If the suppository comes out within the first 10 minutes after insertion, a new suppository may be inserted.

This medication should not be administered to patients with allergies to salicylate components. It should not be used in patients with severe liver or kidney impairment, peptic ulcers, blood coagulation disorders, and infants less than 4 weeks old or premature infants. Caution is advised in patients with bronchial asthma, those who are allergic to other medications, those with mild liver or kidney function, patients with blood disorders, pregnant or nursing women, children, and the elderly. While using this medication, side effects such as diarrhea, nausea, abdominal pain, headache, vomiting, and skin rashes may occur, so caution is necessary. Severe allergic reactions or serious skin reactions, cardiac inflammation, lung diseases, blood abnormalities, liver dysfunction, and kidney issues may occur; if any abnormal symptoms appear, consult a doctor immediately. During the course of treatment with this medication, regular blood tests, liver function tests, and kidney function tests should be conducted, especially if kidney impairment is found, treatment should be discontinued. When taken with other medications, interactions may occur, so consultation with a doctor or pharmacist is necessary, especially with drugs that may cause kidney toxicity. In pregnant or nursing individuals, this medication should only be used cautiously if the benefits are deemed to outweigh the risks; if diarrhea or other unusual reactions occur during breastfeeding, nursing should be stopped. Elderly patients may have reduced kidney function, so regular blood tests should be performed to carefully monitor their condition during the course of treatment with this medication. In case of overdose, symptoms typical of salicylate toxicity may appear, and as there is no specific antidote, treatment should be based on the symptoms. This medication should be stored out of reach of children, and it is important to avoid changing the storage container.

Diarrhea, nausea, abdominal pain, headache, vomiting, rash, hypersensitivity reaction, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), itching, discomfort in the rectum, inability to control bowel movements, anemia, aplastic anemia, agranulocytosis, neutropenia, leukopenia, pancytopenia, thrombocytopenia, eosinophilia, anaphylactic reaction, dizziness, peripheral neuropathy, idiopathic intracranial hypertension, myocarditis, pericarditis, dyspnea, cough, bronchospasm, allergic alveolitis, pulmonary eosinophilia, interstitial lung disease, pulmonary infiltrate, pneumonia, pleuritis, distension, increased amylase, acute pancreatitis, colitis, increased aminotransferases, cholestasis, hepatotoxicity, hepatitis, cholestatic hepatitis, cirrhosis, liver failure, urticaria, erythematous rash, photosensitivity, hair loss, allergic rash, erythema multiforme, myalgia, arthralgia, erythema nodosum, renal dysfunction, acute and chronic interstitial nephritis, nephrotic syndrome, renal failure, nephrolithiasis, urine discoloration, reversible sperm deficiency, hyperthermia, abdominal bloating, belching, increased methemoglobin levels, conjunctivitis, adolescent benign intracranial hypertension, angioedema

This medication should be stored away from direct sunlight, at a cool room temperature. It must also be stored in a closed container to keep air out.

Appearance

White to light yellowish-brown suppository with speckles

Package unit

28 pieces/box