Krofen Tablets (Clonixin Lysinate)

Adult dose

Adults: Administer 125∼250 mg of clonixin lysinate orally 3 times daily.

This medication should be discussed with a doctor or pharmacist before use by individuals who regularly consume more than three alcoholic beverages a day. This drug may cause gastrointestinal bleeding; therefore, caution is needed. It may increase the risk of cardiovascular disease, so patients with a history of heart disease or stroke or those who are at risk should be particularly careful. During treatment, patients should consult a doctor regarding cardiovascular symptoms and should be closely monitored. This medication can cause serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, or perforation. Elderly patients or those with a history of gastrointestinal disease should exercise extra caution, and any gastrointestinal symptoms appearing during use should prompt immediate consultation with medical professionals. Patients with peptic ulcers, individuals with drug-induced gastrointestinal disturbances, those allergic to this medication or its ingredients, and those who have had allergic reactions to aspirin or other non-steroidal anti-inflammatory drugs should not take this medication. Women who are pregnant or may become pregnant, patients with severe liver or kidney dysfunction, or patients with heart failure should also avoid using this medication. This medication should not be taken with other non-steroidal anti-inflammatory drugs, and when taken with blood pressure medications (ACE inhibitors, angiotensin II receptor antagonists), aspirin, diuretics, lithium, methotrexate, anticoagulants, immunosuppressants, antiplatelet drugs, selective serotonin reuptake inhibitors (SSRIs), or corticosteroids, patients must consult with a doctor to consider interaction and side effect risks. Patients with a history of peptic ulcers or the elderly, as well as patients with hypertension, heart failure, or liver or kidney impairment, should consult with medical professionals before taking this medication. Breastfeeding should be avoided or discontinued during treatment with this drug. If symptoms such as nausea, vomiting, diarrhea, abdominal pain, bleeding symptoms, rash, itching, anemia, liver function abnormalities, drowsiness, headache, and dizziness occur during treatment, use should be stopped immediately, and medical advice should be sought. This medication should be used at the lowest possible dose for the shortest duration, and if used for an extended period, regular blood tests and liver and kidney function tests should be performed. It is used as symptomatic therapy for inflammation or pain relief, but should be used cautiously along with appropriate antibiotics for infection-related inflammation. There may be an increased risk of gastrointestinal bleeding when using this medication, so patients with a history of gastrointestinal disease or the elderly should exercise special caution. Patients with hypertension should regularly monitor their blood pressure during the initiation and duration of treatment, as it may worsen. Patients with fluid retention or heart failure should use this medication with caution, and kidney function should be regularly monitored due to the risk of renal damage. If serious rash or hypersensitivity reactions occur, the medication should be discontinued immediately, and asthmatic patients should be particularly careful after confirming if they have aspirin-sensitive asthma. This medication cannot replace corticosteroids, and patients on long-term corticosteroid therapy should taper their dosage gradually. Women who take this medication long-term may experience temporary infertility symptoms.

Gastrointestinal bleeding, severe cardiovascular thrombotic reactions, myocardial infarction, stroke, bleeding of the stomach or intestines, ulcers, perforation, nausea, vomiting, diarrhea, constipation, abdominal pain, peptic ulcer, perforation, shock, rash, itching, anemia, elevated AST, elevated ALT, drowsiness, headache, dizziness, cold sweat, chilliness, abnormal euphoria, jaundice, fulminant hepatitis, hepatic necrosis, hepatic failure, anemia, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, bronchospasm

Drug interactions

Do not take this medication with non-steroidal anti-inflammatory drugs, ACE inhibitors, angiotensin II receptor antagonists, aspirin, diuretics, lithium, methotrexate, coumarin anticoagulants, cyclosporine, tacrolimus, antiplatelet agents, selective serotonin reuptake inhibitors (SSRIs), or corticosteroids. If you are taking medications for treating peptic ulcers such as Misoprostol, discuss this with a doctor or pharmacist.

This medication should be stored in a tightly sealed container to protect it from air and moisture, ideally at room temperature. Avoid exposing it to warm or extremely cold places, and store it in a cool place away from direct sunlight.

Appearance

Pink oblong film-coated tablet

Package unit

10 tablets/package [2 tablets/package x 5], 10 tablets/PTP, 1000 tablets/PTP [10 tablets/PTP x 100]