Robufen Tablet (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2 Adults: 60 mg of loxoprofen sodium (anhydrous) is taken orally three times a day. For single-dose therapy, 60–120 mg is taken orally in one dose. 2. For indication 3 Adults: 60 mg of loxoprofen sodium (anhydrous) is taken orally. Generally, it can be taken 2 times a day, with a maximum daily dose of 180 mg. It is preferable to avoid taking it on an empty stomach.

This medication should be consulted with a doctor or pharmacist before use for individuals who consume large amounts of alcohol daily, as there is a risk of gastrointestinal bleeding. Caution is necessary for individuals with heart or vascular issues or risk factors, as serious cardiovascular problems such as myocardial infarction or stroke may occur. Such symptoms should be reported immediately. Due to the risk of ulcers or bleeding in the gastrointestinal tract, particularly the elderly or those in poor health should closely monitor gastrointestinal symptoms while taking this medication. If any problems are suspected, use should be discontinued immediately and treatment sought. People with a history of peptic ulcers, severe blood disorders, significantly impaired liver or kidney function, severe heart failure, allergies to this medication or its ingredients, and those with a history of allergic reactions to aspirin or other non-steroidal anti-inflammatory drugs should not take this medication. Pregnant women in late pregnancy and breastfeeding women should not take this medication, and patients with inflammatory bowel disease should also exercise caution. Those with a past history of peptic ulcers, blood, liver, or kidney diseases, hypertension or heart failure, the elderly, or asthmatics should use this medication cautiously and monitor their conditions closely during use. If symptoms such as skin rash, itching, hives, difficulty breathing, or low blood pressure appear during use, intake should be halted immediately and a doctor consulted. Gastrointestinal symptoms such as abdominal pain, nausea, vomiting, or blood in stool may occur, and if this happens, a doctor should be notified immediately. Rare neurological symptoms such as drowsiness, dizziness, or headache may appear, so caution is advised when driving or operating machinery. Rarely, abnormalities in liver or kidney function, worsening of heart failure, blood disorders, pneumonia, and severe skin reactions have been reported; if any abnormal symptoms arise, use should be discontinued immediately and medical attention sought. This medication should be used at the lowest effective dose for the shortest duration possible, and regular blood tests and assessments of liver and kidney function are needed with long-term use. The risk of side effects increases if taken with other non-steroidal anti-inflammatory drugs, so they should not be used concurrently. There may be interactions with specific medications, so if other drugs are being taken, a doctor or pharmacist must be informed. Women who are pregnant or may become pregnant should use this medication cautiously, and it should never be taken in late pregnancy. Breastfeeding women should also avoid using this medication. Safety for children has not been established, so it is best not to use this medication in pediatric patients. The elderly are at higher risk for side effects and should use caution while taking this medication. Finally, this medication should be stored out of reach of children and not transferred to other containers for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, shock, anaphylaxis-like symptoms, peptic ulcers, hematemesis, melena, serious gastrointestinal bleeding, perforation, epigastric pain, aseptic meningitis, liver dysfunction (including jaundice), acute renal failure, respiratory distress, asthma attacks, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, acute generalized exanthematous pustulosis, vasculitis.

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• discomfort in the stomach
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication must be kept in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is important to store it at room temperature between 1°C and 30°C, avoiding excessively hot or cold locations.

Appearance

White, round tablet

Package unit

30 tablets, 200 tablets (bottle)