Angivide Sustained Release Tablet 40mg (Isosorbide Dinitrate)

Adult dose

Adults: Administer orally as isosorbide dinitrate at a dose of 40mg once daily or 20mg per dose twice daily. If necessary, the dose may be increased to 40mg per dose twice daily. Adjust the dose appropriately according to age and symptoms.

This medication should not be used in patients with acute circulatory failure, such as shock or sudden vascular collapse. Patients with severe hypotension, glaucoma with eye problems, and those allergic to nitrate components should also avoid this medication. Patients with abnormalities in cardiac muscle or abnormal narrowing of the heart, as well as those with acute myocardial infarction or reduced left ventricular function, should avoid this medication. Particular caution is required when used in patients with cardiogenic shock or who are taking certain erectile dysfunction medications. It should be administered with caution to patients with hypotension, pulmonary hypertension, heart valve problems, and those with blood pressure regulation disorders upon changing positions. Patients with elevated intracranial pressure or fluid accumulation around the heart should also be cautious when using this medication. This medication may cause dizziness, decreased blood pressure, flushing, and symptoms of rapid heartbeat. Gastrointestinal symptoms such as headache, nausea, and vomiting may occasionally occur, and the use should be discontinued immediately if a rash develops on the skin. Especially when using sustained-release formulations, there is a risk of blood pressure dropping too low, worsening angina pectoris, or causing cardiac arrhythmias, so caution is needed. This medication may interact with other drugs; using it alongside certain antihistamines, antihypertensives, and alcohol may pose a risk of significantly lowering blood pressure. Women who are pregnant or could become pregnant should use it cautiously under a physician's guidance, and breastfeeding mothers should avoid taking it or discontinue breastfeeding if possible. Safety for children has not been established, so it is not recommended. Elderly patients may have decreased liver function, leading to increased drug concentration, necessitating caution. Sustained-release formulations should be swallowed whole without chewing or crushing, as doing so may cause side effects like headache. Long-term use of high doses may reduce effectiveness, so dosage should not be significantly increased. Rarely, certain oxygen-carrying substances in the blood may become abnormal, and this medication is unsuitable for the emergency treatment of acute angina pectoris. Re-distribution of blood flow from areas of the lung with poor oxygen exchange can cause hypoxemia, so heart disease patients need to be cautious.

• Dizziness
• hypotension
• feeling of warmth
• flushing
• palpitations
• headache
• weakness
• discomfort
• nausea
• vomiting

This medication should be stored in a tightly sealed container that is not exposed to air, preferably at room temperature around 25 degrees Celsius. This will help maintain the effectiveness of the medication and prevent degradation.

Appearance

White round tablet

Package unit

30 tablets/bottle, 500 tablets/bottle