Hemovidex 0.15% No. 1 Solution

Adult administration

Appropriate alkaline solution for artificial kidney dialysis should be selected based on the patient's condition and the type of artificial kidney apparatus used, and this solution should be diluted with this solution and purified water.

This medication should be used with caution in patients with severe liver dysfunction or severe diabetes, as acetate metabolism may not be adequately processed. Inadequate metabolism of acetate can suppress cardiac function and lead to peripheral vasodilation and hypotension. Patients taking digitalis preparations should also be careful, as serum potassium levels may drop and there is a risk of digitalis toxicity. Symptoms of hyperglycemia may appear during the administration of this drug, particularly during or after dialysis, necessitating careful monitoring of blood glucose levels. If hyperglycemia occurs, appropriate measures such as switching to a glucose-free dialysis solution are needed. Increased fluid intake may lead to weight gain or elevated blood pressure, and in such cases, adjustments for fluid removal should be made. Seizures or discomfort due to hypocalcemia may occur, so it is important to switch to dialysate with high calcium concentrations or administer calcium supplements. Management with active vitamin D3 preparations may be necessary to prevent complications such as osteoporosis, osteomalacia, or fibrous osteitis. Phosphate binders may need to be administered to control serum phosphate levels and prevent ectopic calcification. Dialysis disequilibrium syndrome may cause symptoms such as headache, nausea, vomiting, seizures, and confusion, so measures to adjust dialysis efficiency may be needed. It may also affect the cardiovascular system, leading to hypotension or shock symptoms, so if these symptoms occur, dialysis should be stopped or the efficiency lowered and appropriate treatment administered. The safety during pregnancy has not been established, so it should only be used in pregnant women or those with the potential for pregnancy when the benefits of treatment outweigh the risks. Safety in children has also not been established, so it should be used cautiously in pediatric patients. Elderly patients may have a higher risk of bone complications, requiring regular monitoring and the administration of active vitamin D3 preparations as needed. Dialysis diluents must use strictly purified water, and caution must be taken regarding the risk of dialysis membrane damage or bleeding tendencies. When compounding, do not mix electrolytic solutions for artificial kidney dialysis directly with sodium bicarbonate solutions, and preparation should be done accurately with the specified diluent. If the diluent concentration is too high or low, symptoms such as headache, palpitations, blood pressure abnormalities, and consciousness disturbances may occur, so caution is needed. Ensure that electrolyte concentrations, osmotic pressure, and pH of the dialysis solution are checked before use, and it should be used immediately after mixing. This product should not be used for injection or peritoneal dialysis, and it is preferable to adjust the temperature to body temperature before use.

Serious side effects

• Seizures
• confusion
• shock symptoms
• sudden blood pressure drop
• consciousness disturbances

Mild side effects

Hyperglycemia, weight gain, tendency for increased blood pressure, hypocalcemia, calcium metabolism abnormalities (osteoporosis, osteomalacia, fibrous osteitis, ectopic calcification), dialysis disequilibrium syndrome (headache, nausea, vomiting, seizures, confusion, discomfort, fatigue), hypotension, shock symptoms, increased blood pressure, headache, palpitations, consciousness disturbances, limb numbness, general malaise, chest discomfort, sudden blood pressure drop

Store this medication in a sealed container to prevent air or moisture ingress. It is also advisable to keep it away from direct sunlight and maintain it at room temperature that is not too hot or too cold.

Appearance

A colorless, transparent liquid filled in a white translucent plastic container

Package unit

5.5L/bottle, 10L/bottle