Hemodex 0.15% B2 Solution

Adult administration

The appropriate acidic solution for artificial kidney dialysis should be selected according to the patient's condition and the type of artificial kidney being used, and this solution should be diluted with purified water for use.

This drug should be used with caution in patients with severe liver impairment or severe diabetes where metabolism of acetate is difficult. If acetate is not properly metabolized, cardiac function may be suppressed, leading to symptoms of hypotension due to vasodilation. Patients taking digitalis preparations should also be cautious. This drug can lower serum potassium levels, which could increase the risk of digitalis toxicity. Blood sugar may rise during or after dialysis with this medication; therefore, appropriate measures such as dialysis with glucose-free dialysate should be taken if hyperglycemic symptoms occur. Increased thirst due to this drug may lead to weight gain or elevated blood pressure, and in such cases, body fluid management should be employed to control weight and blood pressure. Calcium levels may decrease during or after dialysis, leading to cramps or discomfort, necessitating appropriate measures such as using dialysate with high calcium concentration or administering calcium supplements. Bone diseases such as osteoporosis, osteomalacia, and fibrous osteitis may develop, hence active vitamin D3 preparations should be administered to maintain bone health. An elevated phosphorus level in the blood may cause ectopic calcification, so it's essential to use phosphate binders to keep phosphorus levels in the normal range. The dialysis disequilibrium syndrome can manifest as headaches, nausea, vomiting, cramps, and altered consciousness, and in such cases, actions should be taken to reduce dialysis efficiency. If circulatory problems occur, causing a sudden decrease in blood volume, symptoms of hypotension or shock may arise; thus, if these symptoms are present, it is necessary to stop dialysis, reduce efficiency, and administer fluids and blood pressure-raising agents. The safety of this drug during pregnancy has not been established, so it should only be used in pregnant women or women of childbearing potential when the benefits outweigh the risks. Safety has also not been established in pediatrics, so caution is needed. Elderly patients should use this drug with a good understanding of its features and may need regular monitoring and administration of vitamin D3 preparations, as prolonged use may lead to bone complications. Dialysis dilution water must be made from strictly purified water, and attention should be given to any damage or bleeding from the dialysis membrane. During preparation, electrolyte solutions for dialysis should not be used in isolation with sodium bicarbonate solution, and they must be accurately prepared with the specified diluent. The electrolyte concentrations, osmotic pressure, and pH of the dialysate should be confirmed before use, and it should be used immediately after mixing. It should not be used for injection or peritoneal dialysis, and it is essential to maintain the balance of the serum osmotic pressure of dialysis patients with that of the dialysate. It is safest to use this drug at a temperature appropriate for body temperature.

Serious side effects

• Cramps
• altered consciousness
• headaches
• sudden blood pressure drop

Mild side effects

• Hyperglycemia
• weight gain
• tendency for elevated blood pressure
• hypocalcemia
• osteoporosis
• osteomalacia
• fibrous osteitis
• ectopic calcification
• headaches
• nausea

This medication should be stored in a sealed container to prevent air or moisture infiltration. It is best kept at room temperature, avoiding excessively hot or cold places.

Appearance

Colorless, transparent liquid filled in a white translucent plastic container.

Package unit

7L/bottle, 12.6L/bottle