Hiroquine Tablet 200 mg (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Adults - The initial dose is 200～400mg per day; when administering 400mg, divide the dose. Once an effect is observed, reduce the dose to 200mg per day; if the effect is inadequate, increase it to 400mg per day. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. * It may take several weeks for this medicine to take effect, whereas adverse effects may occur sooner. * For rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, discontinue use if symptoms do not improve after taking the medicine for 6 months. * When used for photosensitive diseases, administer only when there is substantial exposure. 2. Malaria 1) Treatment Adults - For treatment of acute illness, administer 800mg initially, followed by 400mg 3 more times at 6∼8-hour intervals, for a total of 2g over 2 days. For treatment of acute illness caused by Plasmodium falciparum or Plasmodium vivax (P. falciparum, P. vivax), a single dose of 800mg may also be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg once weekly), starting 2 weeks before exposure.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day; regardless of body weight, it must not exceed the adult dose. 2. Malaria 1) Treatment Children - Administer 10mg/kg of chloroquine initially, followed by 5mg/kg 3 more times at 6-8-hour intervals, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. For children weighing 30∼40kg or less, one tablet (200mg) exceeds the appropriate dose, so administration is not recommended.

This medication should not be used in certain patients. For example, it should not be administered to individuals allergic to this drug or similar compounds, those with existing eye problems, those taking medications that may cause vision impairment, children needing long-term treatment, or women who are pregnant or breastfeeding. Additionally, patients allergic to quinine or those with specific diseases such as psoriasis, liver disease, kidney disease, or cardiovascular diseases should use this medication cautiously. Such patients should receive treatment under strict medical supervision. This medication may affect the eyes, potentially leading to blurred vision, retinal abnormalities, corneal changes, etc. If initial symptoms appear, administration should be stopped immediately, as prolonged use at high doses may risk permanent damage. Dermatological adverse reactions such as skin rashes, hair loss, and urticaria may occur, and in rare cases, severe skin diseases have been reported. If such symptoms develop, consult a physician immediately. Gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain may occur, and the central nervous system may exhibit various symptoms including headache, drowsiness, and hallucinations. Muscle weakness or neurological symptoms should also be monitored. Cardiac side effects may increase the risk of arrhythmias, so caution is advised for patients with heart disease. Liver function abnormalities have also been reported, requiring liver function tests. While taking this medication, regular ophthalmic examinations should be conducted, and any changes in vision should be reported immediately. Furthermore, this medication can interact with other drugs, so inform your doctor of any medications you are taking. It is safer not to use this medication during pregnancy or breastfeeding, especially during breastfeeding, discontinuation is recommended. Overdosing is very dangerous, so adhere strictly to the prescribed dosage, and if an overdose is suspected, seek emergency treatment immediately. Finally, this medication should be stored out of reach of children, and it is advisable to avoid transferring it to another container.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacity, retinopathy, vision impairment, changes in pigmentation, scotoma, halos, glare, skin rash, urticaria, pigmentation changes in skin and mucous membranes, hair discoloration, alopecia, vesicular rash, erythema multiforme, mucocutaneous syndrome, photosensitivity reactions, exfoliative dermatitis, psoriasis flare, acute generalized pustular dermatitis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, muscle weakness, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neurotoxic reactions, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, convulsions, skeletal myopathy, neuromuscular disorders, sensory changes, decreased tendon reflex, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, biventricular hypertrophy, conduction disorders, abnormal liver function test results, fulminant hepatic failure, hepatocyte damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant liver failure, depression, hallucinations, anxiety, agitation, confusion, delusions, mania, sleep disturbances, weight loss, lethargy

This medication should be stored in a sealed container to protect it from air and moisture, maintaining a storage temperature between 1 to 30 degrees Celsius. This will help preserve the medication’s effectiveness for a longer period.

Appearance

White tablet

Package unit

30 tablets/bottle, 300 tablets/bottle