Hanapramidine Tablet

Adult dosage

For oral administration, a dose of 20 mg twice daily (after breakfast, after dinner, or at bedtime) or a dose of 40 mg once daily (at bedtime) is recommended for the treatment of gastric/duodenal ulcers, anastomosis ulcers, upper gastrointestinal bleeding, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. For initial treatment of upper gastrointestinal bleeding, start with an injectable form, and switch to oral administration when possible. To improve gastric mucosal lesions (acute gastritis, acute exacerbation of chronic gastritis), adults should receive a dose of 10 mg twice daily (after breakfast, after dinner, or at bedtime) or a dose of 20 mg once daily (at bedtime). Adjust dosage appropriately based on age and symptoms.

This medication should not be used in patients who are allergic to the ingredients or H2 receptor antagonists. It also contains lactose, so it should not be administered to patients with genetic issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Patients with a history of drug allergies or impaired kidney function should use this medication with caution. Patients with heart disease or liver dysfunction should also use this medication carefully, and the dosage interval should be extended for the elderly. This medication can rarely cause serious allergic reactions, blood disorders, skin diseases, liver dysfunction, muscle damage, cardiac rhythm abnormalities, and kidney problems; if any unusual symptoms occur, stop using it immediately and seek medical attention. Additionally, various side effects such as rash, hives, dyspepsia, blood pressure changes, respiratory problems, and neurological disturbances may occur, so caution is necessary. During treatment, continuously observe symptoms and blood, liver, and kidney function, and consider switching to another treatment if there is no effect. This medication dissolves in the mouth but is not absorbed through the oral mucosa; it must be swallowed with saliva or water. Patients undergoing dialysis should be cautious as the efficacy of some medications may be reduced when used with phosphate binders. If used with certain antifungal agents or specific chemotherapy drugs, the efficacy of this medication or other medications may be reduced, so consultation with a physician is necessary. Women who are pregnant or of childbearing potential should use this medication carefully, and breastfeeding women are advised to discontinue breastfeeding. The safety for pediatric use has not been thoroughly verified, so caution is required. The oral disintegrating tablet form of this medication should be placed on the tongue, allowed to dissolve with saliva, and swallowed; it should not be taken lying down without water. Finally, this medication may mask symptoms of gastric cancer, so it should be used only after confirming the malignancy status.

Serious side effects

Shock, hypersensitivity (anaphylaxis, difficulty breathing, generalized flushing, angioedema, hives), Stevens-Johnson syndrome, Lyell syndrome, liver dysfunction, jaundice, rhabdomyolysis, QT prolongation, ventricular tachycardia, ventricular fibrillation, consciousness disturbance, seizures, interstitial nephritis, acute renal failure, interstitial pneumonia, failure of contraction, pancytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, thrombocytopenia

Mild side effects

• Constipation
• diarrhea
• soft stools
• dry mouth
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• stomatitis
• elevated blood pressure

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, it should be kept out of direct sunlight and stored in a general room temperature area, which should not be too hot or too cold.

Appearance

White round film-coated tablet

Package unit

500 tablets/bottle