GIA-GI Jeong (Ranitidine Hydrochloride)

Adult dose

As ranitidine, a dose of 150 mg is taken orally twice daily, in the morning and at bedtime. For gastric and duodenal ulcers: Administer 150 mg orally twice daily or 300 mg once daily at bedtime. For patients with duodenal ulcers, administer 300 mg orally twice daily, in the morning and at bedtime. In the case of preventative combination therapy for ulcers caused by NSAIDs, the dosing regimen is the same as above.

Child dose

For children aged 8 to 18 years, a single dose of 150 mg (2 mg per kg of body weight) may be administered twice a day.

This medication should not be used in patients who have had an allergy to this drug or its components. Additionally, it should not be administered to patients with a rare blood disorder known as acute porphyria, as it may exacerbate symptoms. In patients with impaired renal function, this drug may remain in the body longer and increase in concentration, so adjustments such as reducing the dosage or increasing the dosing interval are necessary. Patients with decreased liver function or a history of drug allergies, as well as the elderly, should use with caution. When taken in conjunction with NSAIDs, especially in the elderly or those with a history of gastric ulcers, regular monitoring is needed. This drug may mask symptoms of gastric cancer, so patients with gastric ulcers or new dyspeptic symptoms over the age of middle age should confirm that it is not a malignant disease before use. Patients with gastric or duodenal ulcers due to Helicobacter pylori should also undergo eradication therapy. While taking this medication, rare serious allergic reactions, blood abnormalities, liver dysfunction, heart rhythm problems, gastrointestinal symptoms, and psychiatric symptoms may arise. If any unusual symptoms occur, administration should be stopped immediately, and a doctor should be consulted. Particularly in patients with poor renal function, neurological symptoms such as confusion or seizures may occur more easily, so caution is needed. During treatment, regular blood tests, liver function tests, and kidney function tests should be performed to check for abnormalities, and if there is no effect, it is advisable to change to other treatments. Patients taking this medication may experience dizziness or drowsiness, so they should avoid driving or operating hazardous machinery. This medication may interact with other drugs, particularly anticoagulants, so blood coagulation status should be closely monitored when taken together. Women who are pregnant or may become pregnant should carefully consider the risks and benefits of taking this medication, and breastfeeding women should also consult with their doctor before use. The safety of this medication in children has not been sufficiently confirmed, so caution is needed when using it. Elderly patients may have increased drug concentrations due to decreased renal function, thus dosage adjustments and prolonged dosing intervals are necessary. In cases of overdose, while serious issues are rare, treatment such as vomiting, gastric lavage, or possibly blood dialysis may be necessary. Keep this medication out of the reach of children, and avoid transferring it to other containers as this may adversely affect quality.

Serious side effects

• Shock (anaphylactic shock), urticaria, angioedema, chest pain → severe allergic reaction
• Hepatitis (may accompany jaundice), jaundice → liver abnormalities (jaundice)
• Seizures, altered consciousness → severe neurological symptoms
• Thrombocytopenia, agranulocytosis, pancytopenia, aplastic anemia, acquired immune hemolytic anemia → severe edema or urination abnormalities
• Difficulty breathing, bronchospasm → respiratory problems
• Stevens-Johnson syndrome, toxic epidermal necrolysis

Mild side effects

Urticaria, angioedema, rash, fever, bronchospasm, hypotension, chest pain, granulocytopenia, elevated serum creatinine, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, agranulocytosis, pancytopenia, acquired immune hemolytic anemia, eosinophilia, liver dysfunction (elevated AST, ALT, γ-GTP, ALP), bradycardia, heart block, tachycardia, vasculitis, constipation, nausea, vomiting,

This medication should be stored in an airtight container, preferably in a cool, dry place at room temperature. Proper storage will help maintain the drug's effectiveness for a longer period.

Appearance

White round film-coated tablets

Package unit

100, 300 tablets (10 tablets/foil x 10, 30)