Diabex 250 mg Tablets (Metformin Hydrochloride)

Adult dose

The dosage should be determined individually based on drug effectiveness and tolerability and should not exceed the recommended maximum daily dose. This medication should be initially administered at a low dose to reduce gastrointestinal side effects and confirm the minimum dose needed for adequate blood sugar control, typically administered two to three times a day with 500mg taken with meals. The dosage can be gradually increased weekly by 500mg, up to 2.

Child dose

The general starting dose is 500mg once daily, administered during or after meals. Blood sugar levels should be measured one week later to adjust the dose. The maximum daily dose is 2000mg.

This medication can cause severe lactic acidosis or hypoglycemia, so caution is required. It should not be used in patients whose kidney function is moderately impaired or worse, nor in conditions like dehydration, severe infections, or acute myocardial infarction that affect kidney function. Patients with acute and unstable heart failure should also not take this medication. Prior to and after examinations using radiocontrast iodine agents, administration of this medication should be temporarily suspended and can only be resumed once kidney function is confirmed to be normal. It is not indicated for patients with allergies to this medication or similar drugs, Type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. Temporary cessation of use is also necessary prior to and after serious infections, trauma, or surgery, and it should be avoided in patients with poor nutritional status or liver impairment. The use of this medication is also not recommended for pregnant women at risk for placental insufficiency or preeclampsia. During the course of treatment with this medication, irregular meals, excessive exercise, or interactions with other drugs may lead to hypoglycemia or lactic acidosis. This medication may cause side effects such as gastrointestinal disturbances, metallic taste, skin rash, anemia, liver dysfunction, and rarely hypoglycemia; should any unusual symptoms occur, medical consultation is recommended. Kidney function should be regularly monitored, and if there is a decline in function, the medication should be discontinued. Alcohol consumption may increase the risk of lactic acidosis, so it should be avoided while taking this medication. Blood sugar control is very important during pregnancy, so the use of this drug should be carefully considered before and during pregnancy. Since this medication can be excreted in breast milk, breastfeeding status and drug therapy should be discussed with a physician. Elderly individuals often have diminished kidney function, necessitating dosage adjustments and regular monitoring of kidney function. Overdose poses a risk for lactic acidosis, so immediate medical attention is required. This medication may increase the risk of hypoglycemia when used in combination with other hypoglycemic agents, so healthcare providers must be informed of all medications being taken. Regular monitoring of blood sugar and blood tests should be conducted to evaluate treatment effectiveness and side effects during the course of treatment. When administering this medication to children or growing adolescents, careful observation of growth and developmental status is necessary. Lastly, this medication should be stored out of the reach of children and not transferred to another container.

Serious side effects

Lactic acidosis (fatigue, muscle pain, shortness of breath, weakness, abdominal pain, low body temperature, low blood pressure, bradyarrhythmia), urticaria, severe swelling (edema), severe allergic reactions, severe skin adverse reactions (severe rash, blisters, skin peeling, oral/ocular mucosal pain), hypoglycemia, potential liver abnormalities (jaundice), increased risk of lactic acidosis as a result of worsening kidney function

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), sensory symptoms (metallic taste), skin symptoms (erythema, itching, rash), blood system abnormalities (anemia, leukopenia, thrombocytopenia), vitamin B12 deficiency, liver dysfunction, hypoglycemia, urticaria

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is also advisable to keep it away from direct sunlight and store it at room temperature to maintain its efficacy over time.

Appearance

It is a white, round film-coated tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle, 1000 tablets/bottle