Herben Extended Release Capsule 180 mg (Diltiazem Hydrochloride)

Adult dosage

(Oral: extended-release capsules) 1. Adults: Administer 180㎎ of diltiazem hydrochloride orally once daily. The dose may be increased to 360㎎ per dose according to symptoms. 2. Elderly patients and patients with hepatic or renal impairment: The initial dose is 90-120㎎ once daily. Monitor heart rate during treatment; do not increase the dose if the heart rate decreases to 50 beats or less. Adjust the dose appropriately according to age and symptoms. (Oral: extended-release tablets 30㎎) Adults: Administer 30-60㎎ of diltiazem hydrochloride orally per dose, 3 times daily. Adjust the dose appropriately according to age and symptoms. (Oral: extended-release tablets 90㎎) Adults: Administer 90㎎ of diltiazem hydrochloride orally per dose, twice daily. If necessary, the dose may be increased to 90-180㎎ per dose. Adjust the dose appropriately according to age and symptoms. (Injection) Dissolve this product in at least 5㎖ of normal saline injection or dextrose injection and administer as follows. 1. Tachyarrhythmia (supraventricular) Adults: Slowly administer 10㎎ of diltiazem hydrochloride intravenously over approximately 3 minutes. 2. Emergency treatment of abnormal hypertension during surgery ① Intravenous bolus injection Adults: Slowly administer 10㎎ intravenously over approximately 1 minute. ② Intravenous infusion Adults: Infuse 5-15㎍ per kg of body weight intravenously over 1 minute. After reducing blood pressure to the target level, adjust the infusion rate while monitoring blood pressure. 3. Hypertensive emergency (hypertensive crisis) Adults: Infuse 5-15㎍ per kg of body weight intravenously over 1 minute. After reducing blood pressure to the target level, adjust the infusion rate while monitoring blood pressure. Adjust the dose appropriately according to age and symptoms.

This medication should not be used in patients with severe congestive heart failure or severe cardiac conduction disorders, or in patients with severe hypotension. Furthermore, individuals who have had allergic reactions to this medication, or pregnant women or those who may become pregnant should avoid its administration. Patients with severely impaired liver or kidney function should use this medication cautiously as drug metabolism and excretion can be delayed leading to enhanced effects. Various side effects may occur during the use of this medication, such as headaches, dizziness, dyspepsia, skin rashes, respiratory distress, and edema, and if any abnormal symptoms occur, one should consult a doctor immediately. It is particularly important to monitor the heart condition as bradycardia, arrhythmias, or hypotension may occur. This medication has many drug interactions, and using it with certain medications can lead to cardiac rhythm disturbances or changes in blood drug concentration, so it is essential to inform healthcare professionals of any currently used medications. It is safer for pregnant or breastfeeding women to avoid using this medication, and if it must be used, it is recommended to stop breastfeeding. The safety and efficacy in children have not been confirmed, so it is preferable not to use it in pediatric patients. In cases of overdose, severe hypotension, cardiac arrhythmias, or cardiac arrest may occur, and immediate medical treatment should be sought, following the doctor’s guidance for appropriate management. Lastly, as this medication is in capsule form, it should not be opened or chewed, and should be taken whole.

• rhinitis
• headache
• pharyngitis
• constipation
• increased cough
• influenza symptoms
• peripheral edema
• myalgia
• diarrhea
• vomiting

This medication should be stored in a tightly closed container to prevent air and moisture exposure, and it should be kept away from direct sunlight and stored at room temperature.

Appearance

This medication is a white hard capsule filled with white granules.

Package unit

100 capsules (10 tablets/PTPX10), 500 capsules/bottle