Haloxine Tablet 200 mg (Hydroxychloroquine Sulfate)

Adult dose

Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Adults - The initial dose is 200～400mg daily. If 400mg is administered, give it in divided doses. Once an effect is observed, reduce the dose to 200mg daily; if the effect is inadequate, increase it to 400mg daily. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. * Although this medicine may take several weeks to produce an effect, adverse reactions may occur sooner. * Discontinue treatment for rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus if symptoms do not improve after 6 months of treatment. * When used for photosensitive diseases, administer only when exposure to light is expected to be substantial. Malaria Treatment Adults - For treatment of acute disease, administer 800mg initially, followed by 400mg 3 more times at 6∼8-hour intervals, for a total dose of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or Plasmodium vivax (P. falciparum, P. vivax), a single dose of 800mg may also be administered. Prevention Adults - Starting 2 weeks before exposure, administer 6mg/kg once weekly (usually 400mg once weekly).

Child dose

Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. Malaria Treatment Children - Administer 10mg/kg of chloroquine initially, followed by 5mg/kg 3 more times at 6-8-hour intervals, for a total dose of 25mg/kg over 2 days. However, the adult dose must not be exceeded. Prevention Children - Starting 2 weeks before exposure, administer 6mg/kg once weekly. Therefore, for children weighing less than 30∼40kg, even 1 tablet (200mg) exceeds the appropriate dose, so administration is not recommended.

This medication should not be administered to certain patients. For example, patients allergic to this drug or similar compounds, those with retinal issues in the eyes, or those taking medications that can cause visual impairment should not use this drug. In addition, children requiring long-term treatment and women who are pregnant or breastfeeding should not take this drug. Certain patients should use this drug with caution. For instance, patients with specific allergic reactions, psoriasis, liver or kidney diseases, severe gastrointestinal or neurological disorders, blood disorders, and porphyria should use it with care. This drug can cause various eye abnormalities, so regular eye examinations are necessary. If vision becomes cloudy or there are problems distinguishing colors, stop taking the medication immediately and consult a doctor. Side effects have also been reported, including skin rashes, hair loss, and severe skin reactions, so quick action is necessary if abnormal symptoms appear. Gastrointestinal symptoms such as nausea, diarrhea, and loss of appetite may occur, and central nervous system effects may include headache, drowsiness, and hallucinations. Muscle weakness, blood abnormalities, heart rhythm issues, and liver function abnormalities may rarely occur, necessitating caution. This medication may interact with other drugs; therefore, patients taking other medications must inform their doctor or pharmacist. Especially for patients on heart disease or diabetes medications, dosage adjustments may be necessary. Pregnant or breastfeeding women should not use this medication as it may harm the fetus or infant. Overdosage can be very dangerous, so it is essential to adhere to the prescribed dosage and keep it out of the reach of children. If overdose is suspected, immediately visit the hospital for appropriate treatment. While taking this medication, regular eye exams, blood tests, and muscle function tests are essential to detect any abnormal symptoms early.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacity, retinopathy, visual impairment, scotoma, colored halos, glare, skin rash, urticaria, pigmentation changes in the skin and mucous membranes, hair discoloration, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, photosensitivity reactions, exfoliative dermatitis, Sweet's syndrome, severe cutaneous adverse reactions, psoriasis flare-ups, acute generalized pustular psoriasis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, muscle weakness, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restricted neuroexcitability reactions, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood fluctuations, psychosis, seizures, skeletal muscle disease, neuromuscular disease, perceptual changes, decreased reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, left ventricular hypertrophy, conduction disturbances, abnormal liver function test results, fulminant liver failure, hepatocyte damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant hepatic failure, depression, anxiety, agitation, confusion, delusions, mania, sleep disturbances, weight loss, lethargy

This medication should be stored in a tightly closed container to prevent exposure to air or light. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius to ensure the safety of the medication's effectiveness.

Appearance

White sugar-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle