Artriju (Sodium Hyaluronate)

Adult administration

As Sodium Hyaluronate, administer 25 mg once a week for 5 consecutive weeks into the knee joint or shoulder joint (intra-articular space, subacromial bursa, or biceps tendon sheath). Adjust the frequency of administration appropriately based on symptoms. This medication is administered into the knee joint under strict aseptic technique.

This medication should not be administered to certain patients. First, individuals who have had allergic reactions to this medication or any of its ingredients should not use it. Additionally, it should not be administered to those with skin disorders or infections around the joint area. Patients with liver function problems or a history of liver impairment should be cautious, as liver function tests may show abnormal results upon administration of this medication. Those allergic to avian proteins should also refrain from using this medication. Caution should be exercised when using this medication as side effects may occur. Rarely, severe allergic reactions, such as shock, may arise, so careful monitoring of the patient's condition after administration is essential. Symptoms such as swelling of the face or eyelids, rash, or itching may appear, and if such symptoms occur, use should be discontinued immediately. Local pain, swelling, redness, warmth, a sense of pressure, or bruising may occur at the injection site. Additionally, symptoms such as nausea, vomiting, fever, and headache may also develop. In cases of severe arthritis, it is advisable to use this medication after the inflammation has subsided. After administration, it is important to stabilize the joint and avoid excessive movement. If the medication leaks outside of the joint, pain may occur, so it should be injected precisely into the joint. Patients with rheumatoid arthritis or gout may experience temporary worsening of inflammation, necessitating caution. High-impact exercises, such as jogging or tennis, should be avoided for 48 hours after administration to prevent undue stress on the joint. It is advisable not to combine this medication with other intra-articular injection products, as safety and efficacy have not been established. Women who are pregnant or may become pregnant should use this medication cautiously, as its safety is not confirmed, and only when the therapeutic necessity outweighs the risks. During breastfeeding, it is advisable to avoid breastfeeding since this medication may be transferred into breast milk. Safety has not been established for children, so it should be used cautiously only when necessary. Elderly patients may have reduced physical function, so special care must be taken during administration. This medication should be injected into the joint in a sterile environment, and if symptoms do not improve, it should only be administered up to 5 times. If there is a large volume of joint fluid, it is advisable to remove it before injection. It should not be directly injected into blood vessels or eyes, and the appropriate needle size and administration method should be utilized. Prior to use, the ampoule should be shaken to ensure the injection solution is well mixed, and the cutting area should be kept clean. Caution is warranted as mixing with certain disinfectants may cause precipitation, and any opened product should be used immediately and any remaining medication should be discarded.

Serious side effects

• Hives
• edema (facial, eyelids, etc.)
• shock
• hypersensitivity.

Mild side effects

• Facial flushing
• itching
• rash
• transient pain
• swelling
• redness
• warmth
• severe local pressure sensation
• petechiae
• nausea

This medication comes in a sealed container and should be stored at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance

A colorless and transparent viscous liquid filled into a glass vial sealed with rubber stoppers on both ends (part of a prefilled syringe system).

Package unit

2.5 milliliters x 10 vials (for domestic use), 2.5 mL/1 vial (for export), 2.5 milliliters x 10 vials (for export)