Medication info
Trihexin Tablet (Trihexyphenidyl Hydrochloride)

Trihexin Tablet (Trihexyphenidyl Hydrochloride)

Prescription medicationTabletOral
Ingredient · strength
Trihexyphenidyl Hydrochloride›2mg / 1 tablet
Manufacturer / importer
Taeguk Pharmaceutical Co., Ltd.
Appearance
Light yellow round film-coated tablet
Packaging
1000 tablets/bottle
Approval status
Active

MFDS item code 199301084 · Notified 1993.10.07 · Insurance code 644802680

Summary

Main use
Treatment of parkinsonism and antipsychotic-induced movement disorders (excluding tardive dyskinesia) and akathisia
Who takes it
Adults
Adult dose
1. Adults: Administer 1㎎ of trihexyphenidyl hydrochloride orally on the first day and 2㎎ on the second day, then increase the dose by 2㎎ daily to a total daily dose of 6-10㎎, divided into 3-4 doses. 2. For use associated with antipsychotic administration Adults: Administer 2-10㎎ of this medicine daily in 3-4 divided doses. Adjust the dose as appropriate according to age and symptoms.

Ingredients

Manufacturer
Taeguk Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of parkinsonism and antipsychotic-induced movement disorders (excluding tardive dyskinesia) and akathisia

  • Idiopathic Parkinson's disease
  • other forms of Parkinsonism
  • Parkinsonism
  • movement disorders
  • akathisia
View approved original text

This medication is used for idiopathic Parkinson's disease, as well as other forms of Parkinsonism due to encephalitis or atherosclerosis. It is also effective for Parkinsonism and movement disorders induced by antipsychotic medications, and for treating akathisia. In other words, it helps improve symptoms related to Parkinsonism caused by various factors.

How to take

Adult dose

1. Adults: Administer 1㎎ of trihexyphenidyl hydrochloride orally on the first day and 2㎎ on the second day, then increase the dose by 2㎎ daily to a total daily dose of 6-10㎎, divided into 3-4 doses. 2. For use associated with antipsychotic administration Adults: Administer 2-10㎎ of this medicine daily in 3-4 divided doses. Adjust the dose as appropriate according to age and symptoms.

Precautions

This drug should not be used by patients with glaucoma as it may worsen their symptoms. Patients who are allergic to the ingredients in this medication should also not take it. Patients with myasthenia gravis should be cautious as this drug may worsen their symptoms. This medication contains lactose and should not be administered to patients with lactose intolerance. Patients with prostatic hypertrophy or obstructive urinary tract disorders should use this drug with caution as it may worsen their symptoms. Patients with arrhythmias or tachycardia should also be cautious as their symptoms may worsen with this medication. Patients with impaired liver or kidney function should be aware that metabolism of this drug may slow down, leading to severe side effects. Elderly patients or those with hypertension should also manage carefully as the risk of side effects is higher with this medication. Taking this drug in a hot environment can reduce sweating and lead to problems with temperature regulation, so caution is necessary. This medication can affect the nervous system, possibly causing symptoms such as hallucinations, confusion, and dizziness; any unusual symptoms should be reported immediately. Gastrointestinal side effects such as nausea, vomiting, and constipation may occur, so if symptoms are severe, consult a healthcare professional. Urinary difficulties or urinary retention may occur, so caution is necessary if urination is difficult. This drug can cause hypersensitivity reactions such as skin rashes, so discontinue use if any skin issues arise. This medication can cause irregular heartbeats, so caution is needed if experiencing palpitations or irregular heart rhythms. Eye-related side effects such as vision disturbances or pupil dilation may occur, so any changes in vision should be checked immediately. During treatment with this drug, drowsiness or decreased concentration can occur, so avoid driving or operating hazardous machinery. Pregnant or breastfeeding women should avoid this medication as its safety has not been established. Caution is especially needed for children or elderly patients; start with a low dose and closely monitor their condition. Overdose can cause severe central nervous system symptoms and heart or respiratory problems, so it is essential to adhere to prescribed doses. This drug may interact with other medications, so if taking other drugs, it is important to inform healthcare professionals. Combining this medication with alcohol or central nervous system depressants can worsen side effects, so it's safer to avoid such combinations. Regular intraocular pressure and vision tests should be conducted during the treatment period with this medication, and consult a healthcare professional immediately if any unusual symptoms occur.

Side effects

Fever, akinesia, severe muscular rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, leukocytosis, elevated serum CPK, myoglobinuria, renal impairment, confusion, hallucinations, delusions, paranoia, cognitive impairment, visual disturbances, gibberish, hyperreflexia, agitation, dizziness, ataxia, drowsiness, headache, fatigue, chorea, worsening of Parkinson's disease, neuroleptic malignant syndrome, thirst, nausea, vomiting, constipation, loss of appetite, purulent sialadenitis, intestinal dilation, paralytic ileus, dysuria, urinary retention, urinary hesitancy, urinary stasis, rash, palpitations, paradoxical bradycardia, dysregulation, blurred vision, increased intraocular pressure, pupil dilation, angle-closure glaucoma, ciliary muscle paralysis, dry skin, hyperkinesia, psychosis, forgetfulness, weight loss, restlessness, chorea, sleep disturbances, mental confusion, anxiety, behavioral disturbances, nausea, vomiting, persistent euphoria, hyperthermia, muscular rigidity, changes in mental state, autonomic nervous system dysregulation, irregular pulse and blood pressure, deep vein thrombosis, acute exacerbation of Parkinson's syndrome, exacerbation of seizures, atropine poisoning symptoms, taste enhancement and savoring behavior, delirium, coma, paralysis, cardiac and respiratory arrest, death

Not everyone experiences these, and they can vary from person to person.

Storage

This drug is sensitive to light, so it should be stored in a container that does not allow light exposure and kept at a temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the drug's effectiveness.

Appearance and packaging

Appearance

Light yellow round film-coated tablet

Package unit

1000 tablets/bottle

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.