Arukin Tablets (Hydroxychloroquine Sulfate)

Adult dosage

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Adults - The initial dose is 200～400mg per day; if administering 400mg, divide the dose. Once an effect is achieved, reduce the dose to 200mg per day; if the effect is insufficient, increase the dose to 400mg per day. The maintenance dose should be set at the minimum effective dose and should not exceed 6.5mg/kg/day. * It may take several weeks for this medicine to take effect, whereas adverse effects may occur sooner. * For rheumatoid arthritis, juvenile rheumatoid arthritis, and discoid and systemic lupus erythematosus, discontinue use if symptoms do not improve after 6 months of treatment. * When used for photosensitive diseases, administer only when substantial exposure is expected. 2. Malaria 1) Treatment Adults - For treatment of acute disease, administer 800mg initially, followed by 400mg at 6∼8-hour intervals for 3 additional doses, for a total of 2g over 2 days. For acute disease caused by Plasmodium falciparum or Plasmodium vivax, a single dose of 800mg may be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg weekly), starting 2 weeks before exposure.

Children's dosage

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and should not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. 2. Malaria 1) Treatment Children - Administer 10mg/kg of chloroquine initially, followed by 5mg/kg at 6-8-hour intervals for 3 additional doses, for a total of 25mg/kg over 2 days. However, the adult dose should not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. Therefore, it is preferable not to administer this medicine to children weighing less than 30∼40kg, as even 1 tablet (200mg) would exceed the appropriate dose.

This medication should not be used in certain patients. For example, individuals who are allergic to this drug or similar drugs, those with central eye diseases, those taking medications that may affect vision, children requiring long-term treatment, and those who are pregnant or breastfeeding should not take this medication. Furthermore, individuals with quinine allergy, psoriasis, certain blood disorders, liver or kidney disease, and severe gastrointestinal or neurological disorders should use this medication with caution. This medication can cause ocular complications, so regular eye examinations are necessary, and if there are any changes in vision, use should be discontinued immediately. Ocular symptoms may continue to progress even after stopping the medication, so caution is required. Skin rashes or hair loss, severe skin reactions may occur, so if there are changes in skin conditions, immediate consultation with a physician is necessary. Gastrointestinal issues may include nausea, diarrhea, abdominal pain, etc., and if these symptoms are severe, medication should be stopped or the dosage reduced. It may affect the central nervous system, leading to fatigue, headache, hallucinations, anxiety, depression, and other mental symptoms, so if any abnormal symptoms occur, consult a physician. Muscle weakness or neurological issues may occur, and patients taking this medication for a long period should regularly undergo muscle and nerve function tests. It may affect the heart, so those with arrhythmias or cardiac conduction disorders should be cautious when taking this medication. Liver function abnormalities have been reported, so those with liver disease should take this medication according to a physician's instructions. This medication can interact with other drugs, particularly those for heart disease, antibiotics, and diabetes, so it is important to consult with a healthcare professional and monitor closely. Women who are pregnant or breastfeeding should avoid taking this medication, as it may harm the fetus or newborn. In case of overdose, serious side effects may occur, and immediate emergency treatment is required, especially in children. This medication should be kept out of reach of children, and it is safer not to transfer it to another container.

Visual disturbance, retinal abnormality, decreased corneal sensitivity, corneal opacity, retinopathy, visual impairment, scotoma, color ring, glare, skin rash, urticaria, pigment changes in skin and mucous membranes, hair discoloration, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, phototoxicity, exfoliative dermatitis, Sweet syndrome, severe skin adverse reactions, psoriatic flare, acute generalized pustular psoriasis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, myasthenia, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neuroexcitability reactions, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, seizures, skeletal muscle disease, neuromuscular disease, perception changes, decreased reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow depression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, left ventricular hypertrophy, conduction disorder, abnormal liver function test results, fulminant hepatic failure, depression, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, lethargy

This medication should be stored in a sealed container to prevent air or moisture exposure. Additionally, it can only be safely used within the designated period, so it is advisable not to use it after the specified time.

Appearance

White round sugar-coated tablet (export: white round film-coated tablet)

Package unit

Company packaging unit