Diltelan Sustained-Release Capsule (Diltiazem Acidic Polymer Complex)

Adult dosage

(Oral: extended-release capsules) 1. Adults: Administer 180㎎ of diltiazem hydrochloride orally once daily. The dose may be increased to 360㎎ per dose depending on symptoms. 2. Elderly patients and patients with hepatic or renal impairment: Administer 90-120㎎ once daily as the initial dose. Monitor heart rate during treatment; do not increase the dose if it decreases to 50 beats or less. Adjust the dose as appropriate according to age and symptoms. (Oral: extended-release tablets 30㎎) Adults: Administer 30-60㎎ of diltiazem hydrochloride orally per dose 3 times daily. Adjust the dose as appropriate according to age and symptoms. (Oral: extended-release tablets 90㎎) Adults: Administer 90㎎ of diltiazem hydrochloride orally per dose 2 times daily. If necessary, the dose may be increased to 90-180㎎ per dose. Adjust the dose as appropriate according to age and symptoms. (Injection) Dissolve this medicine in at least 5㎖ of normal saline injection or dextrose injection and administer as follows. 1. Tachyarrhythmia (supraventricular) Adults: Slowly administer 10㎎ of diltiazem hydrochloride intravenously over approximately 3 minutes per dose. 2. Emergency treatment of abnormal hypertension during surgery ① Intravenous bolus injection Adults: Slowly administer 10㎎ per dose intravenously over approximately 1 minute. ② Intravenous infusion Adults: Administer 5-15㎍ per ㎏ of body weight by intravenous infusion over 1 minute. After reducing blood pressure to the target level, adjust the infusion rate while monitoring blood pressure. 3. Hypertensive emergency (hypertensive crisis) Adults: Administer 5-15㎍ per ㎏ of body weight by intravenous infusion over 1 minute. After reducing blood pressure to the target level, adjust the infusion rate while monitoring blood pressure. Adjust the dose as appropriate according to age and symptoms.

This medication affects heart function, so it should not be used in patients with severe congestive heart failure or any abnormalities in the cardiac conduction system. Patients with very low blood pressure or in shock, as well as those allergic to this medication, should avoid administration. Pregnant women or those who may become pregnant should not take this medication, and caution is warranted for patients with specific cardiac pacemakers, excluding those with autonomic dysfunction syndrome. Patients with severely impaired liver or kidney function should be cautiously administered, as drug metabolism and excretion may be delayed, increasing the risk of side effects. This drug can cause a variety of side effects, with common symptoms including headache, nasal congestion, cough, constipation, myalgia, and dyspepsia; serious side effects such as cardiac rhythm disturbances or low blood pressure may also occur. If skin rash or allergic reactions occur, the medication should be immediately discontinued, and attention should be paid to any symptoms of liver dysfunction. Discontinuing this medication suddenly may worsen symptoms, so it should be tapered off slowly as instructed by a physician. Blood pressure may drop, leading to dizziness or lightheadedness; caution is advised when working at heights or driving. Patients with bronchial asthma or respiratory hypersensitivity may experience worsening symptoms after taking this medication, thus caution is advised. This drug interacts with many other medications, and side effects may increase or efficacy may change depending on other medications taken concurrently, hence consulting with a doctor or pharmacist is essential. Pregnant or breastfeeding women should avoid this medication or discontinue breastfeeding if necessary. Safety in children has not been sufficiently established, so it should be used cautiously in pediatric patients. In case of overdose, serious heart problems and low blood pressure may occur, so the dosage must be strictly adhered to, and dosages should not be increased without a doctor's guidance. This drug's capsules should not be chewed or opened and must be swallowed whole.

• Rhinitis
• headache
• pharyngitis
• constipation
• increased cough
• influenza symptoms
• peripheral edema
• myalgia
• diarrhea
• vomiting

This medication should be stored in a tightly closed container that is well-ventilated, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage maintains the drug's efficacy and prevents degradation.

Appearance

Sustained-release capsule containing white or grayish spherical granules in a hard capsule that is white on both the top and bottom.

Package unit

30 capsules/bottle, 150 capsules/bottle, 300 capsules/bottle