Oxychlorine Tablet 200 mg (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin disorders Adults - The initial dose is 200～400mg per day. If administering 400mg, divide the dose. If a response occurs after administration, reduce the dose to 200mg per day; if the response is inadequate, increase it to 400mg per day. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. 2. Malaria 1) Treatment Adults - For treatment of acute disease, administer 800mg initially, followed by 400mg at 6∼8-hour intervals for 3 additional doses, for a total of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or Plasmodium vivax, a single dose of 800mg may be administered. 2) Prevention Adults - Administer 6mg/kg (usually 400mg per week) once weekly, starting 2 weeks before exposure. * It may take several weeks for this drug to take effect, whereas adverse effects may occur sooner. * If there is no improvement in symptoms after taking this drug for 6 months for rheumatoid arthritis, juvenile rheumatoid arthritis, discoid or systemic lupus erythematosus, discontinue use. * When used for photosensitive disorders, administer only when there is substantial exposure.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin disorders Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. 2. Malaria 1) Treatment Children - Initially administer 10mg/kg of chloroquine, followed by 5mg/kg at 6-8-hour intervals for 3 additional doses, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. For children weighing 30∼40kg or less, even 1 tablet (200mg) exceeds the appropriate dose; administration is therefore preferably avoided.

This medication should not be used in certain patients. For example, individuals allergic to this drug or similar compounds, those who already have macular degeneration, those taking medications that can cause visual impairments, children requiring long-term treatment, pregnant or breastfeeding women, and individuals with genetic issues such as lactose intolerance should not take this medication. In addition, patients allergic to quinine or those with psoriasis, liver disease, kidney disease, severe gastrointestinal disorders, severe neurological disorders, severe hematologic disorders, porphyria, etc., should use this medication with caution. This drug can cause various adverse eye reactions, including blurred vision, retinal abnormalities, and corneal changes. Although these symptoms may resolve after discontinuing the medication at first, ignoring them can lead to serious damage. Dermatological side effects can include rashes, urticaria, hair loss, pigmentation changes, and rarely severe skin reactions. Gastrointestinal issues may include nausea, diarrhea, loss of appetite, and abdominal pain, while central nervous system reactions have been reported as fatigue, headache, hallucinations, anxiety, and psychiatric symptoms. It may also affect muscles and nerves, causing muscle weakness or neurological dysfunction, and hematological issues may result in anemia or leukopenia. Due to its impact on the heart, arrhythmias or cardiomyopathy may occur, thus caution is advised for individuals with heart disease. Liver function abnormalities have also been reported; if symptoms of liver damage develop, immediate consultation with a healthcare professional is required. Regular ophthalmic examinations are necessary while taking this medication, and use should be discontinued immediately if visual abnormalities occur. Additionally, patients with impaired liver or kidney function must carefully monitor drug concentration and adjust dosage as needed. This medication can interact with other drugs, so it is vital to inform healthcare practitioners about any concurrent medications. Particularly, co-administration with drugs that may induce cardiac arrhythmias can be dangerous. Pregnant or breastfeeding women are advised against using this medication, and breastfeeding should be discontinued during use. Overdosage can result in severe side effects, so immediate emergency treatment should be sought if overdose is suspected. Lastly, this medication should be kept out of the reach of children, and transferring it to another container should be avoided as it may compromise quality.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacity, retinopathy, visual impairment, scotoma, color halos, glare, skin rash, urticaria, pigment changes in skin and mucous membranes, hair depigmentation, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, phototoxic reactions, exfoliative dermatitis, Sweet's syndrome, severe cutaneous adverse reactions, acute generalized exanthematous pustulosis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, weakness, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neurobehavioral response, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, seizures, skeletal muscle myopathy, neuromuscular disease, perceptual changes, decreased tendon reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, cardiac hypertrophy, conduction disorder, abnormal liver function test results, acute liver failure, hepatocellular damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant hepatic failure, depression, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, lethargy

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. The storage temperature should ideally be maintained at room temperature between 1 to 30 degrees Celsius.

Appearance

White, round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle, 400 tablets/bottle