InnoEn 5% Dextrose Sodium Potassium Injection 2

Adult administration

Typically, adults should be administered 500 to 1,000 mL via slow intravenous infusion. The infusion rate should be less than 0.5 g of glucose per kg of body weight per hour. The dosage and infusion rate should be adjusted appropriately according to age, weight, and symptoms.

This medication contains electrolytes such as glucose, potassium, and sodium, so caution is required during intravenous administration. As it contains glucose, it may cause a rapid decrease in the levels of vitamin B1 (thiamine) in the body, so patients at risk of vitamin B1 deficiency should use it with caution. Allergic reactions may occur when administering this medication; therefore, if symptoms such as rash or difficulty breathing arise, the injection should be stopped immediately, and appropriate treatment should be sought. Due to the potassium content, there is a risk of increased serum potassium levels, so patients with poor kidney function or heart diseases should be particularly careful, and potassium levels should be tested frequently. Patients with diabetes or those who have difficulty controlling blood sugar may experience a rapid increase in blood sugar due to this medication; therefore, blood sugar should be monitored frequently, and insulin therapy should be combined if necessary. Patients with hypertension, heart failure, or liver disease should take caution as sodium and chloride components can increase serum sodium and chloride levels, potentially leading to fluid overload or edema. Conversely, children, the elderly, and patients taking specific medications who are at risk of hyponatremia should be monitored carefully for neurological symptoms as this medication may cause sodium levels to drop too low. It may lead to excessive fluid accumulation, so careful adjustment of the dosage and rate of administration while monitoring fluid balance is essential. Patients in very poor nutritional status may develop refeeding syndrome when nutritional supplementation is initiated, so nutrition should be increased slowly, and levels of potassium, phosphorus, and magnesium should be monitored. This medication should not be administered to patients with certain conditions, such as hyperkalemia, fluid overload, hypernatremia, or hyperglycemia, for safety. Patients with severely impaired kidney function or heart failure should use this medication with extra caution, and frequent blood tests may be necessary. Rapid and excessive administration of this medication can lead to serious side effects such as cerebral edema, pulmonary edema, and vasculitis, so the rate and amount of administration should be strictly controlled. Patients who need to limit salt intake due to sodium content or those taking steroid medications should be particularly careful. Regular monitoring of blood sugar, electrolytes, and fluid status is crucial to detect any abnormal signs early. This medication may interact with other medications, so consultations with specialists are necessary if taking medications that increase potassium levels, lithium, or blood sugar-controlling drugs. Pregnant or breastfeeding women, neonates, children, and the elderly should use this medication with increased caution, and particularly, neonates require close observation for blood sugar fluctuations. In case of overdose, administration should be stopped immediately, and appropriate treatment to normalize serum potassium levels should be provided; dialysis may be necessary in some cases. When administering, ensure that the patient's urine output is sufficient, and avoid continuous infusion to prevent issues related to air in the injection container.

Serious side effects

• Anaphylaxis
• cerebral edema
• pulmonary edema
• peripheral edema
• cardiac arrest.

Mild side effects

• Rash
• itching
• blistering at the injection site
• extravasation
• venous thrombosis
• phlebitis
• pain at the injection site
• hyperkalemia
• hyperglycemia
• hyperosmolar hyperglycemic state

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is advisable to keep it at room temperature that is neither particularly cold nor hot. This storage will safely maintain the medication's effectiveness.

Appearance

A colorless, transparent injection solution filled in a transparent plastic container made of high-density polyethylene, packaged externally in a translucent way.

Package unit

500, 1000 milliliters