Innoen Sodium Chloride - Glucose (1:3) Injection

Adult administration

Typically, for adults, 500 to 1,000 mL is administered by slow intravenous infusion. The rate of administration is 300 to 500 mL per hour (75 to 120 drops per minute).

Child administration

In children, the dosage is 50 to 100 mL per hour. Rapid infusion (over 100 mL per hour) should not be used for newborns and premature infants. The dosage and rate of administration should be adjusted appropriately according to age, weight, and symptoms.

This medication contains glucose, which can lead to rapid depletion of vitamin B1 (thiamine) in patients receiving intravenous injections. There is a risk of acute thiamine deficiency worsening; therefore, caution is needed. This medication should not be administered to patients with excessive fluid retention, storage dehydration, or low blood potassium levels. It must be used with caution in patients with impaired kidney function, weak heart function, hypertonic dehydration, reduced urinary output due to urinary obstruction, diabetes, and high blood chloride levels. Rapid or excessive injection of this drug can cause water accumulation in the brain and lungs, swelling of the body, and changes in acidity. Particularly, rapid injections in newborns or premature infants can lead to water intoxication and should be performed with caution. There is also a risk of thrombosis at the injection site, requiring observation. During treatment, blood glucose, blood electrolytes, and body fluid status should be regularly checked for abnormalities. There are reports that a component called DEHP contained in the material of the container may affect reproductive development in pregnant or breastfeeding women, children, and the elderly; however, the actual risk is very low, and it is safer to use if treatment is necessary. During pregnancy, it should be administered only if absolutely necessary while considering the risks to the fetus, and blood glucose changes in the mother and fetus should be carefully monitored during labor. Especially in newborns, due to difficulty in blood glucose regulation, there is a risk of hypoglycemia or hyperglycemia, requiring meticulous monitoring. Care should be taken not to administer too quickly or for prolonged periods in infants and the elderly. In the elderly, if cardiac or renal function is weak, it should be used even more cautiously to reduce circulatory burden. In cases of overdose, treatment with diuretics to eliminate accumulated fluids may be needed. Prior to administration, skin and injection equipment should be thoroughly disinfected to prevent infection, and the medication should be warmed to body temperature in cold weather. After opening, it should be used immediately, and any remaining medication must be discarded. The injection should be administered slowly intravenously. Care should be taken to prevent air from entering the injection container, and connecting multiple containers in succession should be avoided. Finally, this medication should be stored at room temperature, while avoiding excessively hot or cold places.

Serious side effects

Severe edema (cerebral edema, pulmonary edema, peripheral edema), urination abnormalities (caution for patients related to reduced urine volume)

Mild side effects

• Cerebral edema
• pulmonary edema
• peripheral edema
• acidosis
• water intoxication
• thrombosis

This medication should be stored in a sealed container to prevent air or moisture from entering. Additionally, it is best to store it at room temperature that is not too hot or too cold, which helps maintain the medication's effectiveness for a longer period.

Appearance

A colorless, transparent injection solution filled in a plastic container for infusion with a translucent high-density polyethylene outer packaging.

Package unit

500 milliliters